Hamdy Ahmed Abd El-Meguid Mostafa, Ibrahem Mohamed Abd El-Moneam
Department of Oral Medicine and Periodontology of Minia University in Minia, Egypt.
J Contemp Dent Pract. 2010 Jul 1;11(4):E009-16.
Recurrent aphthous ulceration is the most commonly known oral mucosal disease. Quercetin is a useful therapeutic agent for the treatment of colitis and gastric ulcer. The objective of this study was to determine the effect of topical application of quercetin in the treatment of minor aphthous ulcers.
Forty male patients with no known pathology of the oral mucosa other than minor aphthous ulcers were enrolled in this study. Patients were randomly divided into two groups, each consisting of 20 patients. Group 1 (control group) patients used a benzydamine hydrochloride mouthwash three times daily. Group 2 patients placed two to three dabs of quercetin three times daily directly on their ulcers. Clinical evaluation of patients included assessment of ulcer size, pain measure, and interviews regarding the topical application of quercetin in terms of consistency, taste, local tolerability, and ease of application.
The topical application of quercetin cream to minor mouth ulcers relieved pain and produced complete healing in seven of the Group 2 patients (35 percent) in 2-4 days, 18 patients (90 percent) in 4-7 days, and 20 patients (100 percent) in 7-10 days. When comparing the mean ulcer size after 10 days, lesions in the Group 2 patients were smaller than those in Group 1, and the size difference between the two groups was significantly different (p<0.004). Also, 90 percent of patients responded that they appreciated the ease of application when using the topical quercetin, and they did not object to its consistency or taste.
Quercetin is a safe, well-tolerated, and highly effective promising new, adjunctive treatment for healing common aphthous ulcers.
Although aphthous ulcers typically resolve on their own in one to two weeks, the daily topical application of quercetin may be useful in accelerating the healing process of minor aphthous ulcers.
复发性阿弗他溃疡是最常见的口腔黏膜疾病。槲皮素是治疗结肠炎和胃溃疡的有效治疗剂。本研究的目的是确定局部应用槲皮素治疗轻型阿弗他溃疡的效果。
40名除轻型阿弗他溃疡外无其他已知口腔黏膜病变的男性患者纳入本研究。患者被随机分为两组，每组20名患者。第1组（对照组）患者每天使用三次盐酸苄达明漱口水。第2组患者每天三次将两到三滴槲皮素直接涂于溃疡上。对患者的临床评估包括溃疡大小评估、疼痛测量，以及就槲皮素局部应用的稠度、味道、局部耐受性和应用便利性进行访谈。
将槲皮素乳膏局部应用于轻型口腔溃疡可缓解疼痛，第2组中有7名患者（35%）在2 - 4天内完全愈合，18名患者（90%）在4 - 7天内完全愈合，20名患者（100%）在7 - 10天内完全愈合。比较10天后的平均溃疡大小，第2组患者的溃疡病变小于第1组，两组之间的大小差异有显著性（p<0.004）。此外，90%的患者表示他们喜欢使用局部槲皮素时的应用便利性，并且不反对其稠度或味道。
槲皮素是一种安全、耐受性良好且高效的有前景的新型辅助治疗药物，可用于治疗普通阿弗他溃疡。
虽然阿弗他溃疡通常在一到两周内自行愈合，但每天局部应用槲皮素可能有助于加速轻型阿弗他溃疡的愈合过程。
