Monkul E Serap, Hatch John P, Sassi Roberto B, Axelson David, Brambilla Paolo, Nicoletti Mark A, Keshavan Matcheri S, Ryan Neal D, Birmaher Boris, Soares Jair C
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):613-9. doi: 10.1016/j.pnpbp.2007.09.016. Epub 2007 Oct 11.
Prior studies demonstrate structural abnormalities of cerebellar vermis in adult bipolar patients. Cerebella of 16 young bipolar patients (mean age+/-S.D.=15.5+/-3.4) and 21 healthy controls (mean age+/-S.D.=16.9+/-3.8) were examined using magnetic resonance imaging. The volumes of right, left and total cerebellum, vermis, and areas of vermal regions V1 (lobules I-V), V2 (lobules VI-VII), and V3 (lobules VIII-X) were measured. Analysis of covariance, with age, gender, and intra-cranial brain volume as covariates, revealed no significant differences in cerebellum or vermis measures between patients and controls; however, there was a trend to smaller vermis V2 areas in patients (p=0.06). The number of previous affective episodes and vermis area V2 were inversely correlated (partial correlation coefficient=-0.97, P=0.001) in the male bipolar patient group. Our results are preliminary, but consistent with the findings from studies in adult bipolar patients suggesting the involvement of structural changes in cerebellar vermis in the pathophysiology of bipolar disorder.
先前的研究表明成年双相情感障碍患者的小脑蚓部存在结构异常。使用磁共振成像检查了16名年轻双相情感障碍患者（平均年龄±标准差=15.5±3.4）和21名健康对照者（平均年龄±标准差=16.9±3.8）的小脑。测量了右侧、左侧及整个小脑、蚓部以及蚓部区域V1（小叶I-V）、V2（小叶VI-VII）和V3（小叶VIII-X）的体积。以年龄、性别和颅内脑容量作为协变量进行协方差分析，结果显示患者和对照者在小脑或蚓部测量值上无显著差异；然而，患者的蚓部V2区域有变小的趋势（p=0.06）。在男性双相情感障碍患者组中，既往情感发作次数与蚓部V2区域呈负相关（偏相关系数=-0.97，P=0.001）。我们的结果是初步的，但与成年双相情感障碍患者的研究结果一致，提示小脑蚓部的结构变化参与了双相情感障碍的病理生理过程。
