Rascher W, Lingens N, Bald M, Linderkamp O
Department of Neonatology, Universitätskinderklinik, Heidelberg, Germany.
Arch Dis Child. 1991 Apr;66(4 Spec No):395-7. doi: 10.1136/adc.66.4_spec_no.395.
Because raised plasma concentrations of atrial natriuretic peptide indicate volume expansion, we studied the effect of red cell transfusion on plasma atrial natriuretic peptide concentration, packed cell volume, and intravascular volume in eight preterm infants. Red cell transfusion increased red cell mass, packed cell volume and erythrocyte count, but decreased plasma volume. Total blood volume, plasma atrial natriuretic peptide concentration, urine flow rate, and urinary sodium excretion did not change. We conclude that a slow transfusion of less than 10 ml red cells/kg body weight does not cause volume expansion with subsequent atrial natriuretic peptide release thereby affecting the cardiovascular system.
由于血浆心房利钠肽浓度升高表明容量扩张，我们研究了红细胞输注对8名早产儿血浆心房利钠肽浓度、血细胞比容和血管内容量的影响。红细胞输注增加了红细胞量、血细胞比容和红细胞计数，但降低了血浆容量。总血容量、血浆心房利钠肽浓度、尿流率和尿钠排泄量没有变化。我们得出结论，以小于10 ml红细胞/千克体重的速度缓慢输注不会导致容量扩张及随后的心房利钠肽释放，从而影响心血管系统。
