• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Pxl1p, a paxillin-related protein, stabilizes the actomyosin ring during cytokinesis in fission yeast.Pxl1p是一种与桩蛋白相关的蛋白质，在裂殖酵母胞质分裂过程中稳定肌动球蛋白环。
Mol Biol Cell. 2008 Apr;19(4):1680-92. doi: 10.1091/mbc.e07-07-0715. Epub 2008 Feb 13.
2
Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis.粟酒裂殖酵母Pxl1是一种桩蛋白同源物，可调节Rho1活性并参与胞质分裂。
Mol Biol Cell. 2008 Apr;19(4):1727-38. doi: 10.1091/mbc.e07-07-0718. Epub 2008 Feb 6.
3
Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body.Rng2p是裂殖酵母胞质分裂所需的一种蛋白质，是肌动球蛋白环和纺锤极体的一个组成部分。
Curr Biol. 1998 May 21;8(11):611-21. doi: 10.1016/s0960-9822(98)70248-9.
4
Cooperation between Paxillin-like Protein Pxl1 and Glucan Synthase Bgs1 Is Essential for Actomyosin Ring Stability and Septum Formation in Fission Yeast.类桩蛋白Pxl1与葡聚糖合酶Bgs1之间的合作对于裂殖酵母中肌动球蛋白环的稳定性和隔膜形成至关重要。
PLoS Genet. 2015 Jul 1;11(7):e1005358. doi: 10.1371/journal.pgen.1005358. eCollection 2015 Jul.
5
Separate roles of IQGAP Rng2p in forming and constricting the Schizosaccharomyces pombe cytokinetic contractile ring.IQGAP Rng2p 在形成和收缩裂殖酵母细胞有丝分裂收缩环中的分离作用。
Mol Biol Cell. 2013 Jun;24(12):1904-17. doi: 10.1091/mbc.E12-10-0775. Epub 2013 Apr 24.
6
Interactions of Cdc4p, a myosin light chain, with IQ-domain containing proteins in Schizosaccharomyces pombe.粟酒裂殖酵母中肌球蛋白轻链Cdc4p与含IQ结构域蛋白的相互作用。
Cell Struct Funct. 2001 Dec;26(6):555-65. doi: 10.1247/csf.26.555.
7
Paxillin-Mediated Recruitment of Calcineurin to the Contractile Ring Is Required for the Correct Progression of Cytokinesis in Fission Yeast.桩蛋白（Paxillin）介导的钙调神经磷酸酶（Calcineurin）向收缩环的募集对于有丝分裂酵母中胞质分裂的正确进行是必需的。
Cell Rep. 2018 Oct 16;25(3):772-783.e4. doi: 10.1016/j.celrep.2018.09.062.
8
IQGAP-related Rng2p organizes cortical nodes and ensures position of cell division in fission yeast.IQGAP 相关的 Rng2p 组织皮质节点，并确保有丝分裂酵母中细胞分裂的位置。
Curr Biol. 2011 Mar 22;21(6):467-72. doi: 10.1016/j.cub.2011.01.059. Epub 2011 Mar 3.
9
Assembly and architecture of precursor nodes during fission yeast cytokinesis.裂殖酵母胞质分裂过程中前体节点的组装和结构。
J Cell Biol. 2011 Mar 21;192(6):1005-21. doi: 10.1083/jcb.201008171.
10
Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization.裂殖酵母桩蛋白的 Cdk1 磷酸化抑制其胞质分裂环的定位。
Mol Biol Cell. 2021 Aug 15;32(17):1534-1544. doi: 10.1091/mbc.E20-12-0807. Epub 2021 Jun 16.

引用本文的文献

1
Spatial control of secretory vesicle targeting by the Ync13-Rga7-Rng10 complex during cytokinesis.胞质分裂期间Ync13-Rga7-Rng10复合物对分泌囊泡靶向的空间控制。
bioRxiv. 2025 May 14:2025.05.13.653810. doi: 10.1101/2025.05.13.653810.
2
The IQGAP-related RasGAP IqgC regulates cell-substratum adhesion in Dictyostelium discoideum.与IQGAP相关的RasGAP蛋白IqgC调节盘基网柄菌中的细胞-基质黏附。
Cell Mol Biol Lett. 2025 Jan 9;30(1):4. doi: 10.1186/s11658-024-00678-3.
3
Effects of Gene Deletion on Cell Division of Fission Yeast and Its Molecular Mechanism.基因缺失对裂殖酵母细胞分裂的影响及其分子机制
Curr Issues Mol Biol. 2024 Mar 18;46(3):2576-2597. doi: 10.3390/cimb46030164.
4
Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring.裂殖酵母桩蛋白含有两个 Cdc15 结合基序，可牢固募集到胞质分裂环。
Mol Biol Cell. 2022 Apr 1;33(4):br4. doi: 10.1091/mbc.E21-11-0560. Epub 2022 Feb 2.
5
Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization.裂殖酵母桩蛋白的 Cdk1 磷酸化抑制其胞质分裂环的定位。
Mol Biol Cell. 2021 Aug 15;32(17):1534-1544. doi: 10.1091/mbc.E20-12-0807. Epub 2021 Jun 16.
6
LIM domain proteins in cell mechanobiology.LIM 结构域蛋白与细胞力学生物学。
Cytoskeleton (Hoboken). 2021 Jun;78(6):303-311. doi: 10.1002/cm.21677. Epub 2021 Jun 10.
7
Opposite Surfaces of the Cdc15 F-BAR Domain Create a Membrane Platform That Coordinates Cytoskeletal and Signaling Components for Cytokinesis.Cdc15 F-BAR 结构域的相反表面形成一个膜平台，协调细胞分裂过程中的细胞骨架和信号成分。
Cell Rep. 2020 Dec 22;33(12):108526. doi: 10.1016/j.celrep.2020.108526.
8
Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism.进化上多样化的 LIM 结构域蛋白通过保守机制结合应激状态下的肌动蛋白丝。
Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25532-25542. doi: 10.1073/pnas.2004656117. Epub 2020 Sep 28.
9
The Scaffold Proteins Paxillin B and α-Actinin Regulate Septation in via Control of Actin Ring Contraction.支架蛋白桩蛋白 B 和 α-辅肌动蛋白通过控制肌动蛋白环收缩调节 通过分隔。
Genetics. 2020 Jun;215(2):449-461. doi: 10.1534/genetics.120.303234. Epub 2020 Apr 21.
10
DYRK kinase Pom1 drives F-BAR protein Cdc15 from the membrane to promote medial division.DYRK 激酶 Pom1 将 F-BAR 蛋白 Cdc15 从膜上驱逐，以促进中期分裂。
Mol Biol Cell. 2020 Apr 15;31(9):917-929. doi: 10.1091/mbc.E20-01-0026. Epub 2020 Feb 26.

本文引用的文献

1
Splitting of the fission yeast septum.裂殖酵母隔膜的分裂。
FEMS Yeast Res. 2007 Sep;7(6):761-70. doi: 10.1111/j.1567-1364.2007.00266.x. Epub 2007 Jun 27.
2
Assembly of the cytokinetic contractile ring from a broad band of nodes in fission yeast.裂殖酵母中细胞分裂收缩环由广泛的节点带组装而成。
J Cell Biol. 2006 Jul 31;174(3):391-402. doi: 10.1083/jcb.200602032. Epub 2006 Jul 24.
3
Paxillin is required for cell-substrate adhesion, cell sorting and slug migration during Dictyostelium development.在盘基网柄菌发育过程中，桩蛋白对于细胞与底物的黏附、细胞分选和蛞蝓体迁移是必需的。
J Cell Sci. 2005 Sep 15;118(Pt 18):4295-310. doi: 10.1242/jcs.02557.
4
Role of septins and the exocyst complex in the function of hydrolytic enzymes responsible for fission yeast cell separation.Septins和外排体复合物在裂殖酵母细胞分离所负责的水解酶功能中的作用。
Mol Biol Cell. 2005 Oct;16(10):4867-81. doi: 10.1091/mbc.e04-12-1114. Epub 2005 Aug 3.
5
The novel fission yeast protein Pal1p interacts with Hip1-related Sla2p/End4p and is involved in cellular morphogenesis.新型裂殖酵母蛋白Pal1p与Hip1相关的Sla2p/End4p相互作用，并参与细胞形态发生。
Mol Biol Cell. 2005 Sep;16(9):4124-38. doi: 10.1091/mbc.e04-11-0976. Epub 2005 Jun 22.
6
The cell cycle-regulated genes of Schizosaccharomyces pombe.粟酒裂殖酵母的细胞周期调控基因。
PLoS Biol. 2005 Jul;3(7):e225. doi: 10.1371/journal.pbio.0030225. Epub 2005 Jun 28.
7
The alpha-glucanase Agn1p is required for cell separation in Schizosaccharomyces pombe.α-葡聚糖酶Agn1p是粟酒裂殖酵母细胞分离所必需的。
Biol Cell. 2005 Jul;97(7):569-76. doi: 10.1042/BC20040096.
8
End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe.End4/Sla2参与粟酒裂殖酵母中新生长区的建立。
J Cell Sci. 2005 May 1;118(Pt 9):1843-50. doi: 10.1242/jcs.02311. Epub 2005 Apr 12.
9
Split decisions: coordinating cytokinesis in yeast.分歧决策：酵母中细胞分裂的协调
Trends Cell Biol. 2005 Jan;15(1):10-8. doi: 10.1016/j.tcb.2004.11.006.
10
Identification of cell cycle-regulated genes in fission yeast.裂殖酵母中细胞周期调控基因的鉴定。
Mol Biol Cell. 2005 Mar;16(3):1026-42. doi: 10.1091/mbc.e04-04-0299. Epub 2004 Dec 22.

Pxl1p是一种与桩蛋白相关的蛋白质，在裂殖酵母胞质分裂过程中稳定肌动球蛋白环。

Pxl1p, a paxillin-related protein, stabilizes the actomyosin ring during cytokinesis in fission yeast.

作者信息

Ge Wanzhong, Balasubramanian Mohan K

机构信息

Cell Division Laboratory, Temasek Life Sciences Laboratory and the Department of Biological Sciences, National University of Singapore, Singapore.

出版信息

Mol Biol Cell. 2008 Apr;19(4):1680-92. doi: 10.1091/mbc.e07-07-0715. Epub 2008 Feb 13.

DOI:10.1091/mbc.e07-07-0715
PMID:18272786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2291416/
Abstract

Paxillins are a family of conserved LIM domain-containing proteins that play important roles in the function and integrity of the actin cytoskeleton. Although paxillins have been extensively characterized by cell biological and biochemical approaches, genetic studies are relatively scarce. Here, we identify and characterize a paxillin-related protein Pxl1p in the fission yeast Schizosaccharomyces pombe. Pxl1p is a component of the fission yeast actomyosin ring, a structure that is essential for cytokinesis. Cells deleted for pxl1 display a novel phenotype characterized by a splitting of the actomyosin ring in late anaphase, leading to the formation of two rings of which only one undergoes constriction. In addition, the rate of actomyosin ring constriction is slower in the absence of Pxl1p. pxl1Delta mutants display strong genetic interactions with mutants defective in IQGAP-related protein Rng2p and mutants defective in components of the fission yeast type II myosin machinery. Collectively, these results suggest that Pxl1p might cooperate with type II myosin and Rng2p-IQGAP to regulate actomyosin ring constriction as well as to maintain its integrity during constriction.

摘要

桩蛋白是一类保守的含LIM结构域的蛋白质家族，在肌动蛋白细胞骨架的功能和完整性方面发挥重要作用。尽管通过细胞生物学和生物化学方法已对桩蛋白进行了广泛的表征，但遗传学研究相对较少。在此，我们在裂殖酵母粟酒裂殖酵母中鉴定并表征了一种与桩蛋白相关的蛋白质Pxl1p。Pxl1p是裂殖酵母肌动球蛋白环的一个组成部分，该结构对于胞质分裂至关重要。缺失pxl1的细胞表现出一种新的表型，其特征是在后期末期肌动球蛋白环分裂，导致形成两个环，其中只有一个会发生收缩。此外，在没有Pxl1p的情况下，肌动球蛋白环的收缩速率较慢。pxl1Δ突变体与IQGAP相关蛋白Rng2p缺陷的突变体以及裂殖酵母II型肌球蛋白机制成分缺陷的突变体表现出强烈的遗传相互作用。总体而言，这些结果表明Pxl1p可能与II型肌球蛋白和Rng2p-IQGAP协同作用，以调节肌动球蛋白环的收缩，并在收缩过程中维持其完整性。