Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois, USA.
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA.
Cytoskeleton (Hoboken). 2021 Jun;78(6):303-311. doi: 10.1002/cm.21677. Epub 2021 Jun 10.
The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (Lin-11, Isl1, MEC-3) domain-containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity.
肌动蛋白细胞骨架对于维持黏附细胞的力学平衡非常重要，主要是通过调节黏附力和皮质张力来实现的。LIM（Lin-11、Isl1、MEC-3）结构域蛋白参与了众多细胞力学敏感途径。最近的研究发现，LIM 结构域与机械应激的肌动蛋白丝结合，这表明存在一种新颖且广泛保守的机械敏感机制。本综述总结了 LIM 蛋白机械敏感性的现有知识状态。
