LIM 结构域蛋白与细胞力学生物学。
LIM domain proteins in cell mechanobiology.
机构信息
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois, USA.
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA.
出版信息
Cytoskeleton (Hoboken). 2021 Jun;78(6):303-311. doi: 10.1002/cm.21677. Epub 2021 Jun 10.
Abstract
The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (Lin-11, Isl1, MEC-3) domain-containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity.
摘要
肌动蛋白细胞骨架对于维持黏附细胞的力学平衡非常重要，主要是通过调节黏附力和皮质张力来实现的。LIM（Lin-11、Isl1、MEC-3）结构域蛋白参与了众多细胞力学敏感途径。最近的研究发现，LIM 结构域与机械应激的肌动蛋白丝结合，这表明存在一种新颖且广泛保守的机械敏感机制。本综述总结了 LIM 蛋白机械敏感性的现有知识状态。
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本文引用的文献
1
Mechanically tuning actin filaments to modulate the action of actin-binding proteins.通过机械调节肌动蛋白丝来调节肌动蛋白结合蛋白的作用。
Curr Opin Cell Biol. 2021 Feb;68:72-80. doi: 10.1016/j.ceb.2020.09.002. Epub 2020 Oct 23.
2
Mechanosensing through Direct Binding of Tensed F-Actin by LIM Domains.通过 LIM 结构域直接结合紧张的 F-肌动蛋白进行机械感知。
Dev Cell. 2020 Nov 23;55(4):468-482.e7. doi: 10.1016/j.devcel.2020.09.022. Epub 2020 Oct 14.
3
Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism.进化上多样化的 LIM 结构域蛋白通过保守机制结合应激状态下的肌动蛋白丝。
Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25532-25542. doi: 10.1073/pnas.2004656117. Epub 2020 Sep 28.
4
Molecular mechanism for direct actin force-sensing by α-catenin.α-连环蛋白直接感知肌动蛋白力的分子机制。
Elife. 2020 Sep 24;9:e62514. doi: 10.7554/eLife.62514.
5
Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force.Talin 与 RIAM 解离，并在肌动球蛋白力的作用下依次与 vinculin 结合。
Nat Commun. 2020 Jun 19;11(1):3116. doi: 10.1038/s41467-020-16922-1.
6
Force and phosphate release from Arp2/3 complex promote dissociation of actin filament branches.力和磷酸盐从 Arp2/3 复合物中释放出来，促进了肌动蛋白丝分支的解离。
Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13519-13528. doi: 10.1073/pnas.1911183117. Epub 2020 May 27.
7
Plastic Deformation and Fragmentation of Strained Actin Filaments.应变肌动蛋白丝的塑性变形和断裂。
Biophys J. 2019 Aug 6;117(3):453-463. doi: 10.1016/j.bpj.2019.06.018. Epub 2019 Jun 25.
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Torsional stress generated by ADF/cofilin on cross-linked actin filaments boosts their severing.肌动蛋白解聚因子/丝切蛋白对交联肌动蛋白纤维产生的扭转应力会促进其断裂。
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The force-sensitive protein Ajuba regulates cell adhesion during epithelial morphogenesis.力敏蛋白 Ajuba 在上皮形态发生过程中调节细胞黏附。
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Helical rotation of the diaphanous-related formin mDia1 generates actin filaments resistant to cofilin.卷曲相关形态发生因子 mDia1 的螺旋旋转生成抗胞质溶胶蛋白的肌动蛋白丝。
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