[Stratus OCT在抗VEGF治疗中的作用。新生血管性AMD的定性和定量评估]
[The role of Stratus OCT in anti-VEGF therapy. Qualitative and quantitative assessment of neovascular AMD].
作者信息
Bolz M, Ritter M, Polak K, Ahlers C, Hirn C, Prünte C, Golbaz I, Benesch T, Schmidt-Erfurth U
机构信息
Universitätsklinik für Augenheilkunde und Optometrie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Osterreich.
出版信息
Ophthalmologe. 2008 Jul;105(7):650-5. doi: 10.1007/s00347-007-1639-1.
BACKGROUND
The evaluation of OCT3 during anti-VEGF therapy.
METHODS
A total of 29 patients with choroidal neovascularization secondary to AMD received 3 intravitreal injections of ranibizumab. OCT examination and visual acuity testing (ETDRS) were performed before therapy onset, after 1 week and after 1, 2 and 3 months.
RESULTS
The central retinal thickness (CRT) was assessed correctly by OCT in 128 out of 145 measurements. There was a distinct (84%) but not significant correlation between decrease in central retinal thickness and increase in visual acuity. Incorrect retinal layer segmentation and inadequate CRT measurements were a significant technical limitation.
CONCLUSION
During anti-VEGF therapy, OCT allows documentation and quantification of morphologic retinal changes and in most cases also for an estimation of functional improvement.
背景
抗血管内皮生长因子（VEGF）治疗期间对OCT3的评估。
方法
29例继发于年龄相关性黄斑变性（AMD）的脉络膜新生血管患者接受了3次玻璃体内注射雷珠单抗。在治疗开始前、1周后以及1、2和3个月后进行光学相干断层扫描（OCT）检查和视力测试（ETDRS）。
结果
在145次测量中，OCT正确评估了128次的中心视网膜厚度（CRT）。中心视网膜厚度的降低与视力提高之间存在显著（84%）但不显著的相关性。视网膜层分割错误和CRT测量不足是一个重大技术限制。
结论
在抗VEGF治疗期间，OCT可记录和量化视网膜形态学变化，并且在大多数情况下还可用于估计功能改善情况。
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