Monrozies M, Moreau G, Abousleiman C
J Gynecol Obstet Biol Reprod (Paris). 1976 Apr-May;5(3):377-89.
The authors report 2 new cases of adenoma of the liver in women who had been taking oral contraceptives. They review the world literature and analyse 18 of the 31 cases so far described. They consider the theoretical and practical problems posed by liver adenomata. As far as the theory goes, they think that uninterrupted taking of the pill for several years may cause the liver to become hyperactive in order to neutralise the excessive and permanent oestro-progesterone hormones brought to it. Following this, the liver gland responds with hypertrophy. As far as the practical aspect goes, the clinician is faced with the problem of supervision and clinical examination of the abdomen of women who take the pill for a ling time. Gynaecologist and the general surgeon have to know that there are complications with this tumour and in particular acute intraperitoneal bleeding.
作者报告了2例服用口服避孕药的女性患肝腺瘤的新病例。他们回顾了世界文献,并分析了迄今为止所描述的31例病例中的18例。他们考虑了肝腺瘤所带来的理论和实际问题。就理论而言,他们认为连续数年服用避孕药可能会导致肝脏变得活跃,以中和输送到肝脏的过量且持续的雌激素 - 孕激素。在此之后,肝脏会出现肥大反应。就实际情况而言,临床医生面临着对长期服用避孕药的女性进行腹部监测和临床检查的问题。妇科医生和普通外科医生必须了解这种肿瘤会引发并发症,尤其是急性腹腔内出血。