Piirilä Päivi, Seikkula Tommi, Välimäki Petteri
Laboratory of Clinical Physiology, Meilahti Hospital, HUSLAB, Helsinki, Finland.
Int J Circumpolar Health. 2007 Dec;66(5):449-57. doi: 10.3402/ijch.v66i5.18316.
To compare European (ECSC) and Finnish reference values for single-breath diffusing capacity for carbon monoxide (DL(CO)).
Finnish reference values for DL(CO), specific diffusing capacity (DL(CO)/VA) and total lung capacity (TLC) were compared with ECSC reference values calculated for different age, height and weight groups. In addition, 10 healthy subjects performed the test with both the Finnish method (inhaled volume 90% of vital capacity, VC) and the ECSC method (inhaled volume 100% of VC).
Percentual differences between the ECSC and Finnish reference values for DL(CO), TLC and DL(CO)/VA were calculated. The results of measurements of DL(CO) and TLC by using inhaled volume of 100% of VC and 90% of VC in 10 healthy subjects were compared.
The Finnish DL(CO) reference value for men was 3-12% and for women 8-20% smaller than the ECSC reference value. TLC calculated according to Finnish equations was 2-14% greater than that based on ECSC equations. The ECSC reference value for DL(CO)/VA was about 20% greater than the Finnish reference value in men and 30% greater than that in women. The 10 healthy subjects had significantly higher DL(CO) when measured according to the ECSC method as compared with the Finnish one (p < 0.004).
The Finnish reference values for DL(CO) were about 10% smaller, but TLC 10% and DL(CO)/VA 20-30% greater than ECSC reference values in subjects of the same age, height, weight and gender. The difference in DL(CO) is explained by the different inhaled lung volumes used in the two methods, the difference in lung volumes probably arising from ethnic differences in thoracic cavity.
比较欧洲共同体钢铁联营（ECSC）和芬兰的一氧化碳单次呼吸弥散量（DL(CO)）参考值。
将芬兰的DL(CO)、比弥散量（DL(CO)/VA）和肺总量（TLC）参考值与针对不同年龄、身高和体重组计算的ECSC参考值进行比较。此外，10名健康受试者分别采用芬兰方法（吸入量为肺活量的90%，即VC）和ECSC方法（吸入量为VC的100%）进行测试。
计算ECSC和芬兰的DL(CO)、TLC和DL(CO)/VA参考值之间的百分比差异。比较10名健康受试者吸入量为VC的100%和90%时DL(CO)和TLC的测量结果。
芬兰男性的DL(CO)参考值比ECSC参考值小3% - 12%，女性小8% - 20%。根据芬兰公式计算的TLC比基于ECSC公式的TLC大2% - 14%。男性的ECSC的DL(CO)/VA参考值比芬兰参考值约大20%，女性大30%。与芬兰方法相比，10名健康受试者采用ECSC方法测量时的DL(CO)显著更高（p < 0.004）。
在年龄、身高、体重和性别相同的受试者中，芬兰的DL(CO)参考值比ECSC参考值约小10%，但TLC大10%，DL(CO)/VA大20% - 30%。两种方法中DL(CO)的差异是由所用吸入肺容积不同导致的，肺容积差异可能源于胸腔的种族差异。
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