Kainu Annette, Toikka Jyri, Vanninen Esko, Timonen Kirsi L
a HUCH Heart and Lung Center , Helsinki University Hospital and University of Helsinki , Helsinki , Finland.
b Department of Clinical Physiology , Tampere University Hospital , Tampere , Finland.
Scand J Clin Lab Invest. 2017 Apr;77(2):135-142. doi: 10.1080/00365513.2017.1286519.
Measurement standards for pulmonary diffusing capacity were updated in 2005 by the ATS/ERS Task Force. However, in Finland reference values published in 1982 by Viljanen et al. have been used to date. The main aim of this study was to produce updated reference models for single-breath diffusing capacity for carbon monoxide for Finnish adults. Single-breath diffusing capacity for carbon monoxide was measured in 631 healthy non-smoking volunteers (41.5% male). Reference values for diffusing capacity (DLCO), alveolar volume (VA), diffusing capacity per unit of lung volume (DLCO/VA), and lung volumes were calculated using a linear regression model. Previously used Finnish reference values were found to produce too low predicted values, with mean predicted DLCO 111.0 and 104.4%, and DLCO/VA of 103.5 and 102.7% in males and females, respectively. With the European Coalition for Steel and Coal (ECSC) reference values there was a significant sex difference in DLCO/VA with mean predicted 105.4% in males and 92.8% in females (p < .001). New reference values for DLCO, DLCO/VA, VA, vital capacity (VC), inspiratory vital capacity (IVC), and inspiratory capacity (IC) are suggested for clinical use to replace technically outdated reference values for clinical applications.
美国胸科学会/欧洲呼吸学会特别工作组于2005年更新了肺弥散功能的测量标准。然而，在芬兰，至今仍在使用Viljanen等人于1982年发布的参考值。本研究的主要目的是为芬兰成年人制定更新的单次呼吸一氧化碳弥散功能参考模型。对631名健康非吸烟志愿者（41.5%为男性）进行了单次呼吸一氧化碳弥散功能测量。使用线性回归模型计算了弥散功能（DLCO）、肺泡容积（VA）、单位肺容积弥散功能（DLCO/VA）和肺容积的参考值。结果发现，先前使用的芬兰参考值所产生的预测值过低，男性和女性的平均预测DLCO分别为111.0%和104.4%，DLCO/VA分别为103.5%和102.7%。采用欧洲煤钢共同体（ECSC）参考值时，DLCO/VA存在显著性别差异，男性平均预测值为105.4%，女性为92.8%（p < 0.001）。建议采用新的DLCO、DLCO/VA、VA、肺活量（VC）、吸气肺活量（IVC）和吸气量（IC）参考值用于临床，以取代技术上过时的临床应用参考值。
