Parveen Suphiya, Sahoo Sanjeeb K
Laboratory of Nanomedicine, Institute of Life Sciences, Bhubaneswar, India.
J Drug Target. 2008 Feb;16(2):108-23. doi: 10.1080/10611860701794353.
Cancer is an ever-increasing menace that needs to be curbed soon. Though chemotherapy is successful to some extent, the main drawbacks of chemotherapy is the limited accessibility of drugs to the tumor tissues requiring high doses, their intolerable toxicity, development of multiple drug resistance and their non-specific targeting. Nanoparticles (NPs), an evolution of nanotechnology, have the potential to successfully address these problems related to drug delivery and retention and are considered potential candidates to carry drugs to the desired site of therapeutic action. In this review, we give an overview of the use of clinically applicable NPs mainly for cancer therapy. We also focus on the different types of nanoscale polymer carriers used for the delivery of chemotherapeutic agents and the mechanisms that facilitate their targeted delivery to tumor cells.
癌症是一种日益严重的威胁，需要尽快加以遏制。尽管化疗在一定程度上取得了成功，但化疗的主要缺点是药物进入肿瘤组织的可及性有限，需要高剂量，其毒性难以耐受，会产生多药耐药性，且靶向性不明确。纳米颗粒（NPs）作为纳米技术的一个发展成果，有潜力成功解决这些与药物递送和滞留相关的问题，并被视为将药物运送到治疗作用靶点的潜在候选物。在本综述中，我们概述了临床适用的纳米颗粒主要用于癌症治疗的情况。我们还重点介绍了用于递送化疗药物的不同类型的纳米级聚合物载体，以及促进它们靶向递送至肿瘤细胞的机制。
