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合成生物学纳米设计：利用工程纳米材料开创靶向药物递送技术。

SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials.

作者信息

Cai Qian, Guo Rui, Chen Dafu, Deng Zixin, Gao Jiangtao

机构信息

State Key Lab of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, Fujian, China.

National and Local United Engineering Laboratory of Natural Biotoxin, College of Bee and Biomedical Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.

出版信息

J Nanobiotechnology. 2025 Mar 6;23(1):178. doi: 10.1186/s12951-025-03254-9.

DOI:10.1186/s12951-025-03254-9
PMID:40050980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11884119/
Abstract

Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental and clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic and programmable materials to yield engineered nanomaterials with emerging and specific functionalities. This review elucidates a comprehensive examination of synthetic biology's pivotal role in advancing engineered nanomaterials for targeted drug delivery systems. It begins with exploring the fundamental synergy between synthetic biology and nanotechnology, then highlights the current landscape of nanomaterials in targeted drug delivery applications. Subsequently, the review discusses the design of novel nanomaterials informed by biological principles, focusing on expounding the synthetic biology tools and the potential for developing advanced nanomaterials. Afterward, the research advances of innovative materials design through synthetic biology were systematically summarized, emphasizing the integration of genetic circuitry to program nanomaterial responses. Furthermore, the challenges, current weaknesses and opportunities, prospective directions, and ethical and societal implications of SynBioNanoDesign in drug delivery are elucidated. Finally, the review summarizes the transformative impact that synthetic biology may have on drug-delivery technologies in the future.

摘要

合成生物学与纳米技术的融合代表了一种推动基础和临床生物医学科学发展的变革性方法。在合成生物学-纳米设计中，生物系统被重新设想为动态且可编程的材料，以生产具有新兴和特定功能的工程纳米材料。本综述对合成生物学在推进用于靶向给药系统的工程纳米材料方面的关键作用进行了全面审视。它首先探讨了合成生物学与纳米技术之间的基本协同作用，然后突出了纳米材料在靶向给药应用中的当前现状。随后，该综述讨论了受生物学原理启发的新型纳米材料的设计，重点阐述了合成生物学工具以及开发先进纳米材料的潜力。之后，系统总结了通过合成生物学进行创新材料设计的研究进展，强调了整合基因电路以编程纳米材料响应。此外，还阐明了合成生物学-纳米设计在药物递送方面的挑战、当前的弱点与机遇、未来方向以及伦理和社会影响。最后，该综述总结了合成生物学未来可能对药物递送技术产生的变革性影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/c701facb903f/12951_2025_3254_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/2f114765c233/12951_2025_3254_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/5a9e18aaf740/12951_2025_3254_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/6f9b5aa38a4d/12951_2025_3254_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/b845317d4587/12951_2025_3254_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/5c04e5076668/12951_2025_3254_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/6578571e8e2d/12951_2025_3254_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/c701facb903f/12951_2025_3254_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/2f114765c233/12951_2025_3254_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/5a9e18aaf740/12951_2025_3254_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/6f9b5aa38a4d/12951_2025_3254_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/b845317d4587/12951_2025_3254_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/5c04e5076668/12951_2025_3254_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/6578571e8e2d/12951_2025_3254_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a373/11884119/c701facb903f/12951_2025_3254_Fig7_HTML.jpg

相似文献

[1]
SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials.

J Nanobiotechnology. 2025-3-6

[2]
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[3]
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[4]
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J Biomed Nanotechnol. 2014-9

[5]
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[6]
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Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023

[7]
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J Nanobiotechnology. 2018-9-19

[8]
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Nanomedicine. 2014-7

[9]
Nanomaterial-based ophthalmic drug delivery.

Adv Drug Deliv Rev. 2023-9

[10]
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Biotechnol Prog. 2007

本文引用的文献

[1]
Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke.

ACS Nano. 2025-3-18

[2]
Rational Design of Dual-Targeted Nanomedicines for Enhanced Vascular Permeability in Low-Permeability Tumors.

ACS Nano. 2025-1-28

[3]
Nanodrug-Engineered Exosomes Achieve a Jointly Dual-Pathway Inhibition on Cuproptosis.

Adv Sci (Weinh). 2025-1

[4]
Black phosphorus-based nanoplatforms for cancer therapy: chemistry, design, biological and therapeutic behaviors.

Chem Soc Rev. 2025-1-20

[5]
Drug delivery using gold nanoparticles.

Adv Drug Deliv Rev. 2025-1

[6]
Nanomaterials for stroke diagnosis and treatment.

iScience. 2024-10-9

[7]
On the design of cell membrane-coated nanoparticles to treat inflammatory conditions.

Nanoscale Horiz. 2024-12-16

[8]
Advanced Applications of Nanomaterials in Atherosclerosis Diagnosis and Treatment: Challenges and Future Prospects.

ACS Appl Mater Interfaces. 2024-10-30

[9]
Multifunctional nano co-delivery system for efficiently eliminating neuroblastoma by overcoming cancer heterogeneity.

Biomed Mater. 2024-10-25

[10]
Simvastatin-Loaded Polymeric Nanoparticles: Targeting Inflammatory Macrophages for Local Adipose Tissue Browning in Obesity Treatment.

ACS Nano. 2024-10-8

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