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LHRH analogues do not protect the germinal epithelium during chemotherapy. An experimental animal investigation.

作者信息

Papadopoulos I

机构信息

Department of Urology, University of Kiel, FRG.

出版信息

Urol Res. 1991;19(1):31-4. doi: 10.1007/BF00294018.

DOI:10.1007/BF00294018
PMID:1827558
Abstract

The protective effect of Decapeptyl, a D-Trp6-LHRH analogue, on the germinal epithelium of rats during chemotherapy was examined in an experimental animal study. Four groups were formed consisting of 15 (groups A and B) and 20 (groups C and D) Sprague-Dawley rats, respectively. The animals were treated as follows: group A (control group) was given 0.9% NaCl i.m.; group B (LHRH group) D-Trp6-LHRH analogue (Decapeptyl); group C (LHRH + chemotherapy group) Decapeptyl + cyclophosphamide; group D (chemotherapy group) cyclophosphamide. The gonads were removed before therapy was initiated and on days 13, 52, and 182 after treatment and examined histologically. In addition, follicle-stimulating hormone (FSH) levels in the serum, a sensitive indicator of tubular damage, were determined. The most damaging effects of chemotherapy on histology and hormone levels were observed in the animals in group C, which were additionally treated with LHRH analogues. Therefore, it is not possible to protect the germinal epithelium of the rat with LHRH analogues during chemotherapy.

摘要

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本文引用的文献

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The effects of cancer and cancer therapy on male fertility.癌症及癌症治疗对男性生育能力的影响。
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