Thachil J V, Jewett M A, Rider W D
J Urol. 1981 Aug;126(2):141-5. doi: 10.1016/s0022-5347(17)54421-3.
Multimodality treatments have increased the survival of cancer patients in recent years. With cure the quality of life also should be taken into consideration. Maintenance of the reproductive capacity is of great concern to many young patients. Until now the cause of sterility was attributed to the long-term side effects of treatment when recovery could not be predicted. Pre-treatment sperm banking is advised routinely for many of these patients. Our own observation as well as a few other reports show that cancer itself seems to have an adverse effect on fertility before any form of treatment. As assessed by semen quality the majority of our patients were subfertile when first seen. Hence, sperm banking may be a poor guarantee for future reproduction in these patients.
近年来，多模式治疗提高了癌症患者的生存率。在追求治愈的同时，生活质量也应予以考虑。许多年轻患者非常关注生殖能力的维持。到目前为止，不育的原因被归因于治疗的长期副作用，而恢复情况无法预测。对于许多这类患者，常规建议在治疗前进行精子冷冻保存。我们自己的观察以及其他一些报告表明，癌症本身似乎在任何形式的治疗之前就对生育能力有不利影响。根据精液质量评估，我们的大多数患者初诊时就存在生育力低下的情况。因此，精子冷冻保存对于这些患者未来的生育可能并不是一个可靠的保障。
