Zmirou D, Dechenaux J
CAREPS (Centre Alpin de Recherche Epidémiologique et de Prévention Sanitaire), CHU, Grenoble.
Rev Epidemiol Sante Publique. 1991;39(1):101-10.
Epidemiological and experimental papers on respiratory effects of air pollution published between 1980 and 1988 were reviewed, using a meta-analytical approach. Forty epidemiological papers dealing with sulfur dioxide (SO2) and total suspended particles (TSP) were used to scrutinize the interaction between the two pollutants, and suggested that the effect of the acid gas was enhanced by the joint presence of TSP. Oxidant pollution combining O3 and NO2 was also found more noxious than ozone alone, using 32 experimental design papers. These results stem from the multivariate modelization of the relationship between the relative risk of cough or the relative decrease of FEV1.0, and the pollutants concentration, and illustrated some of the advantages of this quantitative approach to literature review. Underlying physiopathological processes are discussed, in the light of the important literature available on this topic.
采用荟萃分析方法，对1980年至1988年间发表的关于空气污染对呼吸系统影响的流行病学和实验性论文进行了综述。40篇关于二氧化硫（SO₂）和总悬浮颗粒物（TSP）的流行病学论文被用于研究这两种污染物之间的相互作用，结果表明酸性气体的影响会因TSP的共同存在而增强。利用32篇实验设计论文还发现，臭氧（O₃）和二氧化氮（NO₂）结合的氧化剂污染比单独的臭氧更具危害性。这些结果源于咳嗽相对风险或第一秒用力呼气容积（FEV₁.₀）相对下降与污染物浓度之间关系的多变量建模，并说明了这种定量文献综述方法的一些优点。根据关于该主题的重要文献，对潜在的生理病理过程进行了讨论。
