2型糖尿病男性的血清前列腺特异性抗原水平
Serum prostate-specific antigen levels in men with type 2 diabetes.
作者信息
Fukui Michiaki, Tanaka Muhei, Kadono Mayuko, Imai Saeko, Hasegawa Goji, Yoshikawa Toshikazu, Nakamura Naoto
机构信息
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
出版信息
Diabetes Care. 2008 May;31(5):930-1. doi: 10.2337/dc07-1962. Epub 2008 Feb 14.
OBJECTIVE
The aims of this study were to examine if serum prostate-specific antigen (PSA) levels are lower in men with type 2 diabetes compared with those in healthy men and to investigate what factors may be associated with serum PSA levels in men with type 2 diabetes.
RESEARCH DESIGN AND METHODS
We compared the serum PSA levels in 224 diabetic men with those in 1,293 healthy men and investigated the relationships between serum PSA levels and various variables.
RESULTS
Except for men aged 40-49 years, serum PSA levels were lower in diabetic men than in healthy men. Multiple regression analysis demonstrated that age, BMI, and presence of diabetes were independent determinants of serum PSA level.
CONCLUSIONS
Serum PSA levels were lower in diabetic men compared with those in healthy men, which is in line with previous reports that patients with type 2 diabetes are at a decreased risk of prostate cancer.
目的
本研究旨在检验2型糖尿病男性的血清前列腺特异性抗原（PSA）水平是否低于健康男性，并调查哪些因素可能与2型糖尿病男性的血清PSA水平相关。
研究设计与方法
我们比较了224名糖尿病男性与1293名健康男性的血清PSA水平，并研究了血清PSA水平与各种变量之间的关系。
结果
除40 - 49岁男性外，糖尿病男性的血清PSA水平低于健康男性。多元回归分析表明，年龄、体重指数（BMI）和糖尿病的存在是血清PSA水平的独立决定因素。
结论
糖尿病男性的血清PSA水平低于健康男性，这与之前关于2型糖尿病患者患前列腺癌风险降低的报道一致。
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