Blasco E, Gutierrez-Hoyos A, Lojendio M, Cosme A, Arenas J I
Pathology Unit, Hospital Nuestra Señora de Arantzazu, San Sebastián, Spain.
Eur J Cancer. 1991;27(4):501-3. doi: 10.1016/0277-5379(91)90396-u.
The surface epithelium of normal gastric mucosa from patients with gastric adenocarcinoma expressed the type 1 blood group precursor only in Lewis (Le) non-secretor individuals, Le a+b- (se/se, Le/-) and Le a-b- (se/se, le/le). In secretors, the superficial mucosa was negative. Deep areas of the mucosa showed no type 1 precursor regardless of secretor status. Expression of type 1 precursor was anomalously found in neoplastic cells in 14 of 16 Le a-b+ (secretors) patients and in 4 of 5 Le a-b- (secretors) patients. The 1 Le a-b- non-secretor carcinoma expressed type 1 precursor strongly. 6 of 8 Le a+b- non-secretor carcinomas showed positivity for the monoclonal antibody K-21. Thus the type 1 precursor reacted with the non-neoplastic gastric surface of non-secretors but not with those of secretors, and also with most gastric adenocarcinoma regardless of secretor status and Lewis phenotype.
胃腺癌患者正常胃黏膜的表面上皮仅在Lewis（Le）非分泌型个体（Le a+b-，se/se，Le/-和Le a-b-，se/se，le/le）中表达1型血型前体。在分泌型个体中，浅表黏膜呈阴性。无论分泌型状态如何，黏膜深层均未显示1型前体。在16例Le a-b+（分泌型）患者中的14例以及5例Le a-b-（分泌型）患者中的4例的肿瘤细胞中异常发现了1型前体的表达。1例Le a-b-非分泌型癌强烈表达1型前体。8例Le a+b-非分泌型癌中的6例对单克隆抗体K-21呈阳性反应。因此，1型前体与非分泌型个体的非肿瘤性胃表面反应，但不与分泌型个体的反应，并且无论分泌型状态和Lewis表型如何，也与大多数胃腺癌反应。
