Cameron R S, Rakic P
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510.
Glia. 1991;4(2):124-37. doi: 10.1002/glia.440040204.
The present review is focused on the cell lineage relationships underlying gliogenesis in the cerebral cortex. Studies conducted both in vivo and in vitro suggest that the process of cortical gliogenesis involves a hierarchy of progressively restricted progenitor cell pools. In the cerebral cortex, as well as other areas of the central nervous system, glial cells differentiate from one another through a series of steps that can be defined at molecular, structural, and functional levels. Although the precise timing, sequence, and diversity of the steps involved in cortical gliogenesis are still not fully defined, the emerging picture suggests that both cell lineage and cell-cell interactions play a synergetic role in the determination and maintenance of the proper blend of glial cells in the cerebrum.
本综述聚焦于大脑皮质神经胶质生成的细胞谱系关系。体内和体外研究均表明，皮质神经胶质生成过程涉及一系列逐渐受限的祖细胞库。在大脑皮质以及中枢神经系统的其他区域，神经胶质细胞通过一系列在分子、结构和功能层面均可定义的步骤彼此分化。尽管皮质神经胶质生成所涉及步骤的确切时间、顺序和多样性仍未完全明确，但新出现的情况表明，细胞谱系和细胞间相互作用在确定和维持大脑中神经胶质细胞的适当组合方面发挥着协同作用。
