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由可去除羧基导向的区域选择性C-H官能化：钯催化吲哚及相关杂芳环的异常位置进行乙烯基化反应。

Regioselective C-H functionalization directed by a removable carboxyl group: palladium-catalyzed vinylation at the unusual position of indole and related heteroaromatic rings.

作者信息

Maehara Atsushi, Tsurugi Hayato, Satoh Tetsuya, Miura Masahiro

机构信息

Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.

出版信息

Org Lett. 2008 Mar 20;10(6):1159-62. doi: 10.1021/ol8000602. Epub 2008 Feb 16.

DOI:10.1021/ol8000602
PMID:18278932
Abstract

The palladium-catalyzed oxidative vinylation of indole-3-carboxylic acids with alkenes effectively proceeds via directed C-H functionalization and decarboxylation to produce the corresponding 2-vinylated indoles. Similarly, pyrrole-, furan-, and thiophenecarboxylic acids also undergo decarboxylative vinylation.

摘要

钯催化的吲哚 - 3 - 羧酸与烯烃的氧化乙烯基化反应通过定向C - H官能化和脱羧有效地进行，生成相应的2 - 乙烯基化吲哚。同样，吡咯 - 、呋喃 - 和噻吩羧酸也会发生脱羧乙烯基化反应。

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