钌催化的通过区域选择性 C-H 键断裂的杂芳基羧酸与烯烃的氧化乙烯基化反应。
Ruthenium-catalyzed oxidative vinylation of heteroarene carboxylic acids with alkenes via regioselective C-H bond cleavage.
机构信息
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
Org Lett. 2011 Feb 18;13(4):706-8. doi: 10.1021/ol102942w. Epub 2011 Jan 18.
PMID:21244053
Abstract
The ruthenium-catalyzed oxidative vinylation of thiophene-2-carboxylic acids with alkenes efficiently proceeds through directed C-H bond cleavage to give the corresponding 3-vinylated products. Similarly, benzothiophene-, benzofuran-, pyrrole-, and indolecarboxylic acids also undergo regioselective vinylation.
摘要
钌催化的噻吩-2-羧酸与烯烃的氧化乙烯基化反应通过导向的 C-H 键断裂高效进行，得到相应的 3-乙烯基化产物。类似地，苯并噻吩、苯并呋喃、吡咯和吲哚羧酸也经历区域选择性的乙烯基化。
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