Wiwanitkit Viroj
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Diabetes Complications. 2008 Mar-Apr;22(2):144-6. doi: 10.1016/j.jdiacomp.2006.09.004.
The angiotensin-converting enzyme (ACE) displays potent vasoconstrictive effects, attenuation of fibrinolysis, and platelet activation and aggregation. The ACE gene has been the main probable candidate gene predisposing the development of diabetic retinopathy (DR). However, the correlation between ACE gene polymorphism and progression of DR still requires further approval. Here, the author performs a summative analysis on recent previous reports on ACE gene polymorphism and its correlation to DR. The meta-analysis was performed in order to assess the correlation between the pattern of ACE gene polymorphism and DR. From four studies available, the author evaluated type II diabetic patients with (Group 1; n=432) and without DR (Group 2; n=329). The frequency of the DD genotype in Group 1 is not significantly different from that in Group 2 (P>.05). In addition, the author first reports a nonsignificant correlation between ethnicity and ACE gene polymorphism.
血管紧张素转换酶（ACE）具有强大的血管收缩作用、纤溶作用减弱以及血小板活化和聚集作用。ACE基因一直是引发糖尿病视网膜病变（DR）的主要候选基因。然而，ACE基因多态性与DR进展之间的相关性仍需进一步证实。在此，作者对先前关于ACE基因多态性及其与DR相关性的近期报道进行了总结分析。进行荟萃分析是为了评估ACE基因多态性模式与DR之间的相关性。从四项现有研究中，作者评估了患有DR的II型糖尿病患者（第1组；n = 432）和未患DR的II型糖尿病患者（第2组；n = 329）。第1组中DD基因型的频率与第2组相比无显著差异（P>.05）。此外，作者首次报道种族与ACE基因多态性之间无显著相关性。
