Barba Maddalena, Terrenato Irene, Schünemann Holger J, Fuhrman Barbara, Sperati Francesca, Teter Barbara, Gallucci Michele, D'Amato Alberto, Muti Paola
Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy.
Urology. 2008 Jul;72(1):183-7. doi: 10.1016/j.urology.2007.09.065. Epub 2008 Feb 15.
To examine the relationship between the indicators of sexual and somatic development (ie, age at first shaving and maximal shoe size) and adolescent anthropometric characteristics (ie, body size at age 10 to 13 years) and prostate cancer risk.
We analyzed the data from a population-based case-control study in Erie and Niagara Counties, New York. The participants were 64 men with incident, primary, histologically confirmed, clinically apparent (Stage B and greater) prostate cancer and 218 controls, who had been frequency matched by age and residential area. Information regarding the variables of interest was self-reported. We compared the adjusted mean age at first shaving and age at maximal shoe size and calculated the odds of body size at ages 10 to 13 years using logistic regression models.
The patients showed no evidence of older age at first shaving (adjusted mean, 18.0 versus 17.8 years, P = 0.46) or significant evidence of older age at the maximal shoe size (20.1 versus 17.6 years, P <0.05). The participants who defined themselves as being as heavy as or heavier than their peers at age 10 to 13 years showed a decreased prostate cancer risk compared with participants who were thinner than their peers (odds ratio 0.36, 95% confidence interval 0.15 to 0.83; and odds ratio 0.38, 95% confidence interval 0.17 to 0.87, respectively).
Our results support a role for the indicators of somatic development and adolescent body size in predicting prostate cancer risk, suggesting that risk determinants operating early in life affect men's subsequent prostate cancer risk.
研究性发育和身体发育指标（即首次剃须年龄和最大鞋码）与青少年人体测量特征（即10至13岁时的身体尺寸）及前列腺癌风险之间的关系。
我们分析了纽约伊利县和尼亚加拉县一项基于人群的病例对照研究的数据。参与者包括64例新诊断的、原发性、经组织学确诊、临床症状明显（B期及以上）的前列腺癌男性患者和218名对照者，后者按年龄和居住地区进行了频数匹配。有关感兴趣变量的信息通过自我报告获得。我们比较了调整后的首次剃须平均年龄和最大鞋码年龄，并使用逻辑回归模型计算了10至13岁时身体尺寸的比值比。
患者在首次剃须年龄方面没有证据显示年龄更大（调整后平均年龄，18.0岁对17.8岁，P = 0.46），在最大鞋码年龄方面也没有明显证据显示年龄更大（20.1岁对17.6岁，P <0.05）。与比同龄人瘦的参与者相比，那些在10至13岁时认为自己与同龄人一样重或更重的参与者患前列腺癌的风险降低（比值比分别为0.36，95%置信区间0.15至0.83；以及比值比0.38，95%置信区间0.17至0.87）。
我们的结果支持身体发育指标和青少年身体尺寸在预测前列腺癌风险方面的作用，表明生命早期起作用的风险决定因素会影响男性随后患前列腺癌的风险。
