单磷酰脂质A对C3H小鼠脂多糖反应性和脂多糖缺陷型菌株中抑制性T细胞活性表达的差异影响。

Differential effects of monophosphoryl lipid A on expression of suppressor T cell activity in lipopolysaccharide-responsive and lipopolysaccharide-defective strains of C3H mice.

作者信息

Ekwunife F S, Taylor C E, Fauntleroy M B, Stashak P W, Baker P J

机构信息

Department of Natural Sciences, University of Maryland-Eastern Shore, Princess Anne 21853.

出版信息

Infect Immun. 1991 Jun;59(6):2192-4. doi: 10.1128/iai.59.6.2192-2194.1991.

DOI:10.1128/iai.59.6.2192-2194.1991

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC257987/

Abstract

Lipopolysaccharide (LPS)-responsive and LPS-defective strains of C3H mice did not differ in the capacity to make an antibody response to type III pneumococcal polysaccharide or in the degree of thymus-derived suppressor cell (Ts) activity generated following exposure to type III pneumococcal polysaccharide. However, treatment with monophosphoryl lipid A (MPL) abolished the expression of Ts function in LPS-responsive but not LPS-defective mice. Since this effect was elicited by different preparations of MPL, it appears to be a general property of MPL mediated by direct action of MPL on activated Ts.

摘要

C3H小鼠的脂多糖（LPS）反应性和LPS缺陷型品系在对III型肺炎球菌多糖产生抗体反应的能力上，或在暴露于III型肺炎球菌多糖后产生的胸腺来源抑制性细胞（Ts）活性程度上并无差异。然而，单磷酰脂质A（MPL）处理消除了LPS反应性小鼠而非LPS缺陷型小鼠中Ts功能的表达。由于不同的MPL制剂均可引发这种效应，所以这似乎是MPL通过直接作用于活化的Ts所介导的一种普遍特性。

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本文引用的文献

1

Regulation of the antibody response to pneumococcal polysaccharide by thymus-derived cells.胸腺来源细胞对肺炎球菌多糖抗体应答的调节

Rev Infect Dis. 1981 Mar-Apr;3(2):332-41. doi: 10.1093/clinids/3.2.332.

2

Beneficial modification of the endotoxin molecule.内毒素分子的有益修饰

J Biol Response Mod. 1984;3(1):1-9.

3

Endotoxin-induced T lymphocyte proliferation.内毒素诱导的T淋巴细胞增殖。

J Immunol. 1983 Apr;130(4):1774-9.

4

Lipid A and immunotherapy.脂多糖A与免疫疗法。

Rev Infect Dis. 1984 Jul-Aug;6(4):567-72. doi: 10.1093/clinids/6.4.567.

5

Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.用III型肺炎球菌多糖免疫的小鼠的B细胞激活抗原特异性抑制性T细胞。

J Exp Med. 1983 Sep 1;158(3):703-17. doi: 10.1084/jem.158.3.703.

6

Direct evidence for the involvement of T suppressor cells in the expression of low-dose paralysis to type III pneumococcal polysaccharide.抑制性T细胞参与III型肺炎球菌多糖低剂量麻痹表达的直接证据。

J Immunol. 1982 Mar;128(3):1059-62.

7

Application of transformations to normalize the distribution of plaque-forming cells.应用变换来使噬斑形成细胞的分布正常化。

J Immunol. 1974 Jul;113(1):51-7.

8

Characterization of the antibody response to type 3 pneumococcal polysaccharide at the cellular level. II. Studies on the relative rate of antibody synthesis and release by antibody-producing cells.在细胞水平对3型肺炎球菌多糖抗体反应的特征描述。II. 对抗体产生细胞抗体合成和释放相对速率的研究。

Immunology. 1971 Apr;20(4):481-92.

9

Characterization of the antibody response to type 3 pneumococcal polysaccharide at the cellular level. I. Dose-response studies and the effect of prior immunization on the magnitude of the antibody response.在细胞水平上对3型肺炎球菌多糖抗体反应的特征分析。I. 剂量反应研究以及先前免疫对抗体反应强度的影响。

Immunology. 1971 Apr;20(4):469-80.

10

Quantitative and qualitative studies on the primary antibody response to pneumococcal polysaccharides at ehe cellular level.在细胞水平上对肺炎球菌多糖的初次抗体反应进行的定量和定性研究。

J Immunol. 1969 Dec;103(6):1342-8.

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