海藻糖二霉菌酸酯对Ⅲ型肺炎球菌多糖抗体反应的佐剂作用。
Adjuvant effects of trehalose dimycolate on the antibody response to type III pneumococcal polysaccharide.
作者信息
Baker P J, Fauntleroy M B, Stashak P W, Hiernaux J R, Cantrell J L, Rudbach J A
机构信息
National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
出版信息
Infect Immun. 1989 Mar;57(3):912-7. doi: 10.1128/iai.57.3.912-917.1989.
Treatment with trehalose dimycolate (TDM) increases the magnitude of the immunoglobulin M (IgM) antibody response of mice to type III pneumococcal polysaccharide (SSS-III). Such enhancement is demonstrable over a wide range of immunizing doses and does not require thymus-derived (T) cells to be elicited. Although young adult mice immunized with SSS-III do not usually make anti-SSS-III antibodies of the IgG1 and IgG3 classes, antibodies of one or both isotypes were produced after immunization and treatment with TDM and/or monophosphoryl lipid A (MPL); the additive nature of the effect produced by both TDM and MPL suggests that the two immunomodulators act by different mechanisms. TDM and MPL have different effects on the induction and expression of low-dose immunological paralysis, a form of unresponsiveness known to be mediated by suppressor T cells. The relevance of these findings to the modes of action of TDM and MPL is discussed.
海藻糖二霉菌酸酯（TDM）处理可增强小鼠对III型肺炎球菌多糖（SSS-III）的免疫球蛋白M（IgM）抗体反应强度。在广泛的免疫剂量范围内均可证实这种增强作用，且无需胸腺来源的（T）细胞来引发。尽管用SSS-III免疫的成年小鼠通常不会产生IgG1和IgG3类抗SSS-III抗体，但在用TDM和/或单磷酰脂质A（MPL）免疫和处理后会产生一种或两种同种型的抗体；TDM和MPL产生的效应具有相加性，这表明这两种免疫调节剂的作用机制不同。TDM和MPL对低剂量免疫麻痹的诱导和表达有不同影响，低剂量免疫麻痹是一种已知由抑制性T细胞介导的无反应形式。讨论了这些发现与TDM和MPL作用模式的相关性。
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