Costa-Silva J H, Lima C R, Silva E J R, Araújo A V, Fraga M C C A, Ribeiro E Ribeiro A, Arruda A C, Lafayette S S L, Wanderley A G
Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Pernambuco 50740-521, Brazil.
J Ethnopharmacol. 2008 Mar 28;116(3):495-500. doi: 10.1016/j.jep.2007.12.016. Epub 2008 Jan 6.
Carapa guianensis (Meliaceae), known as Andiroba in Brazil, has been used by Amazon Rainforest indigenous communities for treatment of coughs, convulsions, skin diseases, arthritis, rheumatism, ear infections, to heal wounds and bruises and as an insect repellent. Carapa guianensis seed oil (SO) was evaluated for its acute and subacute toxicity (30 days) by the oral route in Wistar rats. In the acute toxicity test, SO (0.625-5.0g/kg, n=5/sex) did not produce any hazardous symptoms or deaths. The subacute treatment with SO (0.375, 0.75 and 1.5g/kg, n=10/group) failed to change body weight gain, food and water consumption. Hematological analysis showed no significant differences in any of the parameters examined. However, in the biochemical parameters, there was an increase in the alanine aminotransferase (ALT) serum level (29%) in the group SO 1.5g/kg. In addition, absolute and relative liver weights were increased at the doses of 0.75g/kg (23.4 and 19.1%) and 1.5g/kg (18.7 and 33.1%). In conclusion, acute and subacute administration of Carapa guianensis seed oil did not produce toxic effects in male Wistar rats. However, the increase in the ALT serum level and in both absolute and relative liver weights may indicate a possible hepatic toxicity.
巴西红木（楝科），在巴西被称为安第罗巴，已被亚马逊雨林的原住民社区用于治疗咳嗽、惊厥、皮肤病、关节炎、风湿病、耳部感染、伤口和瘀伤愈合以及作为驱虫剂。通过口服途径对Wistar大鼠评估了巴西红木种子油（SO）的急性和亚急性毒性（30天）。在急性毒性试验中，SO（0.625 - 5.0g/kg，n = 5/性别）未产生任何有害症状或死亡。用SO（0.375、0.75和1.5g/kg，n = 10/组）进行的亚急性治疗未能改变体重增加、食物和水的消耗。血液学分析显示在所检查的任何参数中均无显著差异。然而，在生化参数方面，SO 1.5g/kg组的丙氨酸转氨酶（ALT）血清水平升高（29%）。此外，在0.75g/kg（23.4%和19.1%）和1.5g/kg（18.7%和33.1%）剂量下，肝脏绝对重量和相对重量均增加。总之，巴西红木种子油的急性和亚急性给药在雄性Wistar大鼠中未产生毒性作用。然而，ALT血清水平以及肝脏绝对重量和相对重量的增加可能表明存在潜在的肝毒性。
