Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, 50740-521, Brazil.
J Ethnopharmacol. 2009 Dec 10;126(3):468-73. doi: 10.1016/j.jep.2009.09.013. Epub 2009 Sep 23.
Schinus terebinthifolius Raddi (Anacardiaceae) has long been used in traditional Brazilian medicine, especially to treat inflammatory and haemostatic diseases.
The objective of this study was to evaluate the acute and subacute toxicity (45 days) of Schinus terebinthifolius via the oral route in Wistar rats of both sexes.
For the acute toxicity test, the dried extract of Schinus terebinthifolius bark was administered in doses from 0.625 to 5.0 g/kg (n=5/group/sex) and in the subacute toxicity test the following doses were used: 0.25, 0.625 and 1.5625 g/kg/day (n=13/group/sex), for 45 consecutive days.
In the acute toxicity test, Schinus terebinthifolius did not produce any toxic signs or deaths. The subacute treatment with Schinus terebinthifolius did not alter either the body weight gain or the food and water consumption. The hematological and biochemical analysis did not show significant differences in any of the parameters examined in female or male groups, except in two male groups, in which the treatment with Schinus terebinthifolius (0.25 and 0.625 g/kg) induced an increase of mean corpuscular volume values (2.9 and 2.6%, respectively). These variations are within the physiological limits described for the specie and does not have clinical relevance.
The acute and subacute administration of the dried extract of Schinus terebinthifolius bark did not produced toxic effects in Wistar rats.
Schinus terebinthifolius Raddi（漆树科）在传统的巴西医学中被长期使用，特别是用于治疗炎症和止血疾病。
本研究的目的是通过口服途径评估 Schinus terebinthifolius 树皮的急性和亚急性毒性（45 天）在雄性和雌性 Wistar 大鼠中。
在急性毒性试验中，Schinus terebinthifolius 树皮的干提取物以 0.625 至 5.0 g/kg 的剂量（n=5/组/性别）给药，在亚急性毒性试验中使用以下剂量：0.25、0.625 和 1.5625 g/kg/天（n=13/组/性别），连续 45 天。
在急性毒性试验中，Schinus terebinthifolius 未产生任何毒性迹象或死亡。Schinus terebinthifolius 的亚急性治疗未改变雄性或雌性大鼠的体重增加或食物和水的消耗。血液学和生化学分析未显示雌性或雄性大鼠组中检查的任何参数有显著差异，除了两个雄性大鼠组，其中 Schinus terebinthifolius（0.25 和 0.625 g/kg）治疗导致平均红细胞体积值增加（分别为 2.9%和 2.6%）。这些变化在该物种描述的生理范围内，没有临床意义。
口服 Schinus terebinthifolius 树皮干提取物的急性和亚急性给药在 Wistar 大鼠中未产生毒性作用。
