Jones R N, Goldstein F W, Zhou X Y
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
Antimicrob Agents Chemother. 1991 Mar;35(3):584-6. doi: 10.1128/AAC.35.3.584.
MDL 62211 is the amide derivative of the teicoplanin complex and MDL 62873 is a more focused amide derivative of the teicoplanin A2-2 peak. Each investigational compound had nearly identical activity and was 2- to 16-fold more active than teicoplanin or vancomycin. The MDL 62873 MICs for 90% of the strains tested were as follows: Staphylococcus aureus, oxacillin susceptible, 0.12 micrograms/ml; S. aureus, oxacillin resistant, 0.25 micrograms/ml; coagulase-negative staphylococci (CNS), oxacillin susceptible, 0.25 micrograms/ml; and CNS, oxacillin resistant, 2 micrograms/ml. CNS isolates from France were generally more susceptible than those tested in the United States. Teicoplanin-resistant U.S. isolates were usually Staphylococcus haemolyticus (1.8% of all tested strains), for which MICs ranged from 32 to greater than 128 micrograms/ml. MDL 62873 was not active against the Bacteroides fragilis group but was generally effective against gram-positive anaerobic strains.
MDL 62211是替考拉宁复合物的酰胺衍生物，MDL 62873是替考拉宁A2 - 2峰更具针对性的酰胺衍生物。每种研究化合物都具有几乎相同的活性，且活性比替考拉宁或万古霉素高2至16倍。MDL 62873对90%受试菌株的最低抑菌浓度（MIC）如下：对苯唑西林敏感的金黄色葡萄球菌为0.12微克/毫升；对苯唑西林耐药的金黄色葡萄球菌为0.25微克/毫升；对苯唑西林敏感的凝固酶阴性葡萄球菌（CNS）为0.25微克/毫升；对苯唑西林耐药的CNS为2微克/毫升。来自法国的CNS分离株通常比在美国测试的那些更敏感。美国的耐替考拉宁分离株通常是溶血葡萄球菌（占所有受试菌株的1.8%），其MIC范围为32至大于128微克/毫升。MDL 62873对脆弱拟杆菌群无活性，但对革兰氏阳性厌氧菌株通常有效。
