Bannerman T L, Wadiak D L, Kloos W E
Department of Microbiology, North Carolina State University, Raleigh 27695-7614.
Antimicrob Agents Chemother. 1991 Sep;35(9):1919-22. doi: 10.1128/AAC.35.9.1919.
Twenty-four Staphylococcus species and their subspecies were examined for their susceptibilities to teicoplanin by disk diffusion (30-micrograms disk) and agar dilution for the determination of MICs. Moderately susceptible and resistant clinical strains were further tested for their susceptibilities to oxacillin and vancomycin. Teicoplanin resistance was not observed in the reference strains of the various Staphylococcus species isolated from healthy volunteers or animals. However, the novobiocin-resistant species Staphylococcus saprophyticus, Staphylococcus cohnii, Staphylococcus xylosus, Staphylococcus arlettae, Staphylococcus kloosii, and Staphylococcus gallinarum were less susceptible to teicoplanin (MIC, 2 to 8 micrograms/ml) than most of the novobiocin-susceptible species were (MIC, 0.5 to 4 micrograms/ml). Clinical isolates of coagulase-negative species were generally less susceptible to teicoplanin than were reference strains. Seven percent of the Staphylococcus epidermidis clinical strains were moderately susceptible (MIC, 16 micrograms/ml) to teicoplanin. Of these strains, 70% were oxacillin resistant. For Staphylococcus haemolyticus strains, 11% were resistant (MIC, greater than 16 micrograms/ml) and 21% were moderately susceptible to teicoplanin. Of these strains, 95% were oxacillin resistant, No strains of S. epidermidis or S. haemolyticus were intermediate or resistant to vancomycin. Teicoplanin appears to be less active in vitro against oxacillin-resistant S. haemolyticus. However, teicoplanin is an effective antimicrobial agent against many Staphylococcus species.
通过纸片扩散法（30微克纸片）和琼脂稀释法测定最低抑菌浓度（MIC），检测了24种葡萄球菌及其亚种对替考拉宁的敏感性。对中度敏感和耐药的临床菌株进一步检测了它们对苯唑西林和万古霉素的敏感性。从健康志愿者或动物中分离出的各种葡萄球菌参考菌株未观察到对替考拉宁耐药。然而，耐新生霉素的腐生葡萄球菌、科氏葡萄球菌、木糖葡萄球菌、阿氏葡萄球菌、克氏葡萄球菌和鸡葡萄球菌对替考拉宁的敏感性（MIC为2至8微克/毫升）低于大多数耐新生霉素的菌株（MIC为0.5至4微克/毫升）。凝固酶阴性菌的临床分离株通常比参考菌株对替考拉宁更不敏感。7%的表皮葡萄球菌临床菌株对替考拉宁中度敏感（MIC为16微克/毫升）。在这些菌株中，70%对苯唑西林耐药。对于溶血葡萄球菌菌株，11%耐药（MIC大于16微克/毫升），21%对替考拉宁中度敏感。在这些菌株中，95%对苯唑西林耐药。没有表皮葡萄球菌或溶血葡萄球菌菌株对万古霉素中介或耐药。替考拉宁在体外对耐苯唑西林的溶血葡萄球菌的活性似乎较低。然而，替考拉宁是一种针对许多葡萄球菌的有效抗菌剂。
