伴有高凝血因子VIII水平及深静脉血栓形成的过敏性紫癜：一种关联还是巧合？

Henoch-Schonlein purpura with high factor VIII levels and deep venous thrombosis: an association or coincidence?

作者信息

Topaloglu Rezan, Bayrakci Umut Selda, Cil Barbaros, Orhon Diclehan, Bakkaloglu Aysin

机构信息

Department of Pediatric Nephrology and Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

出版信息

Rheumatol Int. 2008 Jul;28(9):935-7. doi: 10.1007/s00296-008-0542-7. Epub 2008 Feb 19.

DOI:10.1007/s00296-008-0542-7

PMID:18283464

Abstract

Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis in children. Although long-term outcome is generally good, serious complications may occur. Thrombosis has been reported only as an extremely rare complication of HSP. Here, we describe a 15-year-old-boy with features of HSP, who developed left main iliac, external iliac and femoral vein thrombosis. Factor VIII (FVIII) and homocystein levels were found to be high. This suggests that HSP itself may lead to a prothrombotic state and increase the risk of developing thrombosis in patients who have any risk factors.

摘要

过敏性紫癜（HSP）是儿童最常见的系统性血管炎。尽管长期预后总体良好，但仍可能发生严重并发症。血栓形成仅被报道为HSP极其罕见的并发症。在此，我们描述一名15岁男孩，具有HSP特征，发生了左主髂静脉、髂外静脉和股静脉血栓形成。发现因子VIII（FVIII）和同型半胱氨酸水平升高。这表明HSP本身可能导致血栓前状态，并增加有任何危险因素的患者发生血栓形成的风险。