过敏性紫癜与中风：脑脊液和血清中的抗磷脂酰乙醇胺抗体

Henoch-Schönlein purpura and stroke: antiphosphatidylethanolamine antibody in CSF and serum.

作者信息

Sokol D K, McIntyre J A, Short R A, Gutt J, Wagenknecht D R, Biller J, Garg B

机构信息

Indiana University School of Medicine, Department of Neurology, James Whitcomb Riley Hospital for Children, Indianapolis 46202-5200, USA.

出版信息

Neurology. 2000 Nov 14;55(9):1379-81. doi: 10.1212/wnl.55.9.1379.

DOI:10.1212/wnl.55.9.1379

PMID:11087785

Abstract

A 15-year-old girl with features of Henoch-Schönlein purpura and brain infarct had a transient IgA antiphosphatidylethanolamine antibody (aPE) in her serum and CSF that disappeared 5 months after presentation. Serum aPE is known to be associated with thrombotic events. The authors found no aPE in the CSF of two control individuals or in the serum of two patients with active Henoch-Schönlein purpura without neurologic involvement. The patient may represent a variant of antiphospholipid antibody syndrome.

摘要

一名患有过敏性紫癜和脑梗死的15岁女孩，其血清和脑脊液中曾出现短暂的IgA抗磷脂酰乙醇胺抗体（aPE），该抗体在发病后5个月消失。已知血清aPE与血栓形成事件有关。作者在两名对照个体的脑脊液中以及两名无神经系统受累的活动性过敏性紫癜患者的血清中均未发现aPE。该患者可能代表抗磷脂抗体综合征的一种变异型。