Besbas N, Erbay A, Saatçi U, Ozdemir S, Bakkaloglu A, Ozen S, Topaloglu R
Department of Pediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Clin Exp Rheumatol. 1998 Jan-Feb;16(1):95-8.
To evaluate the changes in the plasma levels of thrombomodulin (TM), tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PA1-1) as indices of endothelial injury/activation and fibrinolysis in childhood Henoch-Schönlein purpura (HSP).
Twenty-six children with HSP aged between 4-15 years and 10 healthy controls were included in the study. Blood samples were taken from these patients at admission and 6-12 weeks after healing of skin rash and arthritis. Plasma levels of TM, t-PA and PAI-1 activities and t-PA and PAI-1 antigen (Ag) levels were measured.
The plasma levels of TM, t-PA Ag and PAI-1 Ag in patients during the acute phase were significantly different from the controls. The difference in TM between the acute phase and recovery in patients was also significant. The decrease in plasma levels of t-PA Ag and PAI-1 Ag in patients between the acute and recovery phases was not significant. t-PA activity was significantly higher in the acute phase than in the recovery phase.
We suggest that increased levels of TM, t-PA, and PAI-1 activity may reflect the presence of endothelial injury and/or activation and fibrinolytic activation in patients with HSP.
评估血浆中血栓调节蛋白（TM）、组织型纤溶酶原激活物（t-PA）和纤溶酶原激活物抑制剂-1（PAI-1）水平的变化，以此作为儿童过敏性紫癜（HSP）内皮损伤/激活和纤溶的指标。
本研究纳入了26例年龄在4至15岁之间的HSP患儿和10名健康对照者。在这些患者入院时以及皮疹和关节炎愈合后6至12周采集血样。检测血浆中TM、t-PA和PAI-1的活性以及t-PA和PAI-1抗原（Ag）水平。
急性期患者血浆中TM、t-PA Ag和PAI-1 Ag水平与对照组有显著差异。患者急性期与恢复期的TM差异也很显著。患者急性期与恢复期之间血浆中t-PA Ag和PAI-1 Ag水平的降低不显著。急性期t-PA活性显著高于恢复期。
我们认为TM、t-PA和PAI-1活性水平升高可能反映了HSP患者存在内皮损伤和/或激活以及纤溶激活。
