核苷类似物的抗BK病毒活性。
Anti-BK virus activity of nucleoside analogs.
作者信息
Randhawa Parmjeet, Zemlicka Jiri, Sauerbrei Andreas, Meier Chris, Hostetler Karl Y, Beadle James R, Farasati Noush Afarin, Huang Yuchen, Bradley Matthews
机构信息
Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Room Medical Center, Pittsburgh, PA 15213, USA.
出版信息
Antimicrob Agents Chemother. 2008 Apr;52(4):1519-21. doi: 10.1128/AAC.01241-07. Epub 2008 Feb 19.
Abstract
Polyomavirus BK is an important pathogen in transplant recipients with no effective therapy. This study demonstrates that alkoxyalkyl esters of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and fatty acid derivatives of 9-[2-(phosphonomethyoxy)ethyl]adenine (P393 and P405) are potent and selective inhibitors of BK virus replication in vitro, with a 50% effective concentration in the micromolar-to-nanomolar range.
摘要
多瘤病毒BK是移植受者中的一种重要病原体，目前尚无有效治疗方法。本研究表明，（S）-9-（3-羟基-2-膦酰甲氧基丙基）腺嘌呤的烷氧基烷基酯和9-[2-（膦酰甲氧基）乙基]腺嘌呤的脂肪酸衍生物（P393和P405）在体外是BK病毒复制的强效和选择性抑制剂，其50%有效浓度在微摩尔至纳摩尔范围内。
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