Tuerk Peter W, Mueller Martina, Egede Leonard E
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Diabetes Care. 2008 May;31(5):869-73. doi: 10.2337/dc07-1662. Epub 2008 Feb 19.
Researchers have only just begun to investigate physician-related effects on medical outcomes. Such research is necessary for developing empirically informed practice guidelines and policy. The primary goal of this study was to investigate whether glucose management in type 2 diabetes varies by randomly assigned physicians over the course of a year in treatment. A second goal of the study was to investigate whether physician-related effects vary across differential patient characteristics. A tertiary goal was to investigate potential patient-level effects on glucose management.
Hierarchical linear models were used to investigate A1C among 1,381 patients, nested within 42 randomly assigned primary care physicians at a Veterans Affairs medical center in the southeastern U.S. The primary outcome measure was change in A1C over the course of 1 year in treatment. On average, each study physician had 33 patients with diabetes.
Overall, physician-related factors were associated with statistically significant but modest variability in A1C change (2%), whereas patient-level factors accounted for the majority of variation in A1C change (98%). Physician effects varied by patient characteristics, mattering more for black patients, patients aged 65 years, and patients whose glucose management improved over the treatment year.
The results of this study indicate that differential physician effects have minimal impact on glycemic control. Results suggest that it is logical to support policies encouraging the development of patient-level behavioral interventions because that is the level that accounts for the majority of variance in glycemic control.
研究人员才刚刚开始调查医生相关因素对医疗结果的影响。此类研究对于制定基于实证的实践指南和政策而言是必要的。本研究的主要目标是调查在一年的治疗过程中,2型糖尿病患者的血糖管理是否因随机分配的医生而异。该研究的第二个目标是调查医生相关影响是否因患者特征的差异而有所不同。第三个目标是调查患者层面的因素对血糖管理的潜在影响。
采用分层线性模型对美国东南部一家退伍军人事务医疗中心的42名随机分配的初级保健医生所负责的1381名患者的糖化血红蛋白(A1C)进行调查。主要结局指标是治疗1年内A1C的变化。平均而言,每位参与研究的医生有33名糖尿病患者。
总体而言,医生相关因素与A1C变化中具有统计学意义但适度的变异性相关(2%),而患者层面的因素则占A1C变化变异的大部分(98%)。医生的影响因患者特征而异,对黑人患者、65岁的患者以及在治疗年度内血糖管理得到改善的患者影响更大。
本研究结果表明,医生之间的差异影响对血糖控制的影响最小。结果表明,支持鼓励开展患者层面行为干预的政策是合理的,因为这是导致血糖控制差异的主要层面。