Pramming S, Thorsteinsson B, Bendtson I, Binder C
Steno Memorial Hospital, Gentofte, Denmark.
Diabet Med. 1991 Apr;8(3):217-22. doi: 10.1111/j.1464-5491.1991.tb01575.x.
The frequency of symptomatic hypoglycaemic episodes was studied in 411 randomly selected conventionally treated Type 1 diabetic out-patients. Between two consecutive visits to the out-patient clinic each patient filled in a questionnaire at home. The number of hypoglycaemic episodes was then recorded prospectively in a diary for 1 week. From the questionnaires, the (retrospective) frequencies of mild and severe symptomatic hypoglycaemia were 1.6 and 0.029 episodes patient-1 week-1. From the diaries, the (prospective) frequencies of mild and severe hypoglycaemic episodes were 1.8 and 0.027 patient-1 week-1. Symptomatic hypoglycaemia was more frequent on working days than during weekends (1.8:1) and more frequent in the morning than during the afternoon, evening, and night (4.5:2.2:1.4:1). The symptoms of hypoglycaemia were non-specific, heterogeneous, and weakened with increasing duration of diabetes. During their diabetic life, 36% of the patients had experienced hypoglycaemic coma. The frequency of hypoglycaemia was positively, but only weakly, correlated with insulin dose, number of injections, percentage unmodified insulin of the total dose, and HbA1c (mild hypoglycaemia only). The frequency was also negatively, but weakly, correlated with age and HbA1c (episodes with coma only), but not correlated with sex, duration of diabetes, or patients' ratings of worries about mild and severe hypoglycaemia.
对411名随机选取的接受常规治疗的1型糖尿病门诊患者的症状性低血糖发作频率进行了研究。在两次连续门诊就诊期间，每位患者在家填写一份问卷。然后前瞻性地在日记中记录1周内的低血糖发作次数。根据问卷，轻度和重度症状性低血糖的（回顾性）发作频率分别为1.6次/患者·周和0.029次/患者·周。根据日记，轻度和重度低血糖发作的（前瞻性）频率分别为1.8次/患者·周和0.027次/患者·周。症状性低血糖在工作日比周末更频繁（1.8:1），且在上午比下午、晚上和夜间更频繁（4.5:2.2:1.4:1）。低血糖症状不具特异性、异质性，且随着糖尿病病程延长而减弱。在其糖尿病病程中，36%的患者曾经历过低血糖昏迷。低血糖发作频率与胰岛素剂量、注射次数、总剂量中未修饰胰岛素的百分比以及糖化血红蛋白呈正相关，但仅为弱相关（仅轻度低血糖）。发作频率也与年龄和糖化血红蛋白呈负相关，但为弱相关（仅昏迷发作），且与性别、糖尿病病程或患者对轻度和重度低血糖的担忧程度无关。
