Macfarlane P I, Walters M, Stutchfield P, Smith C S
Institute of Child Health, Royal Liverpool Children's Hospital, Alder Hey, U.K.
Diabet Med. 1989 Sep-Oct;6(7):627-30. doi: 10.1111/j.1464-5491.1989.tb01240.x.
A prospective study of symptomatic hypoglycaemia was conducted in 47 children over a 14-week period using a questionnaire completed at home for each episode of hypoglycaemia. Twenty-nine children (62%) experienced 150 episodes during the study. The average incidence was once every 33 days (range 0-5.2 mo-1). Hypoglycaemia occurred more frequently in children with lowest haemoglobin A1 levels. Episodes were not randomly distributed in time; hypoglycaemia occurred significantly more frequently in the evening, in the early morning and around midday. The majority of episodes were judged to be mild but 2 children had nocturnal convulsions and glucagon was used on three occasions. Symptomatic nocturnal hypoglycaemia occurred one or more times in 30% of the children. Daytime episodes were manifested by tremor, feeling weak, dizziness, pallor, and other symptoms and signs. In 46% of cases the cause was not evident to parents or children, but 25% were related to physical activity.
一项针对47名儿童的症状性低血糖前瞻性研究在14周内进行，通过让患儿在家中针对每一次低血糖发作填写问卷来收集数据。在研究期间，29名儿童（62%）经历了150次低血糖发作。平均发生率为每33天一次（范围为0 - 5.2次/月）。血红蛋白A1水平最低的儿童低血糖发作更为频繁。发作在时间上并非随机分布；低血糖在傍晚、清晨和中午前后发作更为频繁。大多数发作被判定为轻度，但有2名儿童出现夜间惊厥，且有三次使用了胰高血糖素。30%的儿童出现过一次或多次症状性夜间低血糖。白天的发作表现为震颤、乏力、头晕、面色苍白及其他症状和体征。在46%的病例中，家长或患儿并不清楚病因，但25%的发作与体力活动有关。
