Research Center, Ste-Justine Hospital, University of Montreal, Montréal, PQ, Canada H3T 1C5.
PPAR Res. 2008;2008:364784. doi: 10.1155/2008/364784.
Investigating the metabolic functions of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) has been extremely rewarding over the past years. Uncovering the biologic roles of PPARgamma and its mechanism of action has greatly advanced our understanding of the transcriptional control of lipid and glucose metabolism, and compounds such as thiazolidinediones which directly regulate PPARgamma have proven to exhibit potent insulin-sensitizer effects in the treatment of diabetes. We review here recent advances on the emerging role of growth hormone releasing peptides in regulating PPARgamma through interaction with scavenger receptor CD36 and ghrelin GHS-R1a receptor. With the impact that these peptides exert on the metabolic pathways involved in lipid metabolism and energy homeostasis, it is hoped that the development of novel approaches in the regulation of PPAR functions will bring additional therapeutic possibilities to face problems related to metabolic diseases.
在过去的几年中，研究核受体过氧化物酶体增殖物激活受体γ（PPARγ）的代谢功能收获颇丰。揭示 PPARγ 的生物学作用及其作用机制极大地促进了我们对脂质和葡萄糖代谢转录控制的理解，并且直接调节 PPARγ 的化合物，如噻唑烷二酮类，已被证明在治疗糖尿病方面具有有效的胰岛素增敏作用。在这里，我们回顾了生长激素释放肽通过与清道夫受体 CD36 和生长激素释放肽 GHS-R1a 受体相互作用调节 PPARγ 的新作用的最新进展。鉴于这些肽对涉及脂质代谢和能量平衡的代谢途径的影响，希望调节 PPAR 功能的新方法的发展将为解决与代谢疾病相关的问题带来更多的治疗可能性。
