Bellnier D A
Division of Radiation Biology, Roswell Park Cancer Institute, Buffalo, NY 14263.
J Photochem Photobiol B. 1991 Jan;8(2):203-10. doi: 10.1016/1011-1344(91)80060-u.
The tumoricidal response of subcutaneously growing SMT-F adenocarcinoma implanted into syngeneic DBA/2 mice to Photofrin II-sensitized photodynamic therapy (PDT) was statistically significantly enhanced by the addition of a single dose of intravenously administered recombinant human tumor necrosis factor-alpha (rHuTNF-alpha). The interaction appeared to be approximately additive, i.e. tumor response to PDT plus rHuTNF-alpha was about the same as that observed by doubling the PDT dose. Conversely, rHuTNF-alpha did not significantly potentiate the cutaneous phototoxicity in mouse feet due to PDT. These data suggest that combination therapy should be considered for improving tumor response while retaining treatment selectivity in human malignancies.
将同基因DBA/2小鼠皮下种植的SMT-F腺癌对二血卟啉醚敏化光动力疗法（PDT）的杀肿瘤反应，通过静脉注射单剂量重组人肿瘤坏死因子-α（rHuTNF-α）而在统计学上得到显著增强。这种相互作用似乎大致是相加性的，即肿瘤对PDT加rHuTNF-α的反应与将PDT剂量加倍时所观察到的反应大致相同。相反，rHuTNF-α并没有显著增强PDT对小鼠足部皮肤的光毒性。这些数据表明，在人类恶性肿瘤中，为了提高肿瘤反应同时保持治疗选择性，应考虑联合治疗。
