Interventional Therapy Department, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China; Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, College of Mathematics and Science, University of Central Oklahoma, Edmond, OK, 73034, USA.
Department of Oncology, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
Cancer Lett. 2019 Feb 1;442:429-438. doi: 10.1016/j.canlet.2018.10.044. Epub 2018 Nov 24.
Phototherapy is a non-invasive or minimally invasive therapeutic strategy. Immunotherapy uses different immunological approaches, such as antibodies, vaccines, immunoadjuvants, and cytokines to stimulate the host immune system to fight against diseases. In cancer treatment, phototherapy not only destroys tumor cells, but also induces immunogenic tumor cell death to initiate a systemic anti-tumor immune response. When combined with immunotherapy, the effectiveness of phototherapy can be enhanced. Because of their special physical, chemical, and sometimes immunological properties, nanomaterials have also been used to enhance phototherapy. In this article, we review the recent progress in nanotechnology-based phototherapy, including nano-photothermal therapy, nano-photochemical therapy, and nano-photoimmunological therapy in cancer treatment. Specifically, we focus on the immunological responses induced by nano-phototherapies.
光疗是一种非侵入性或微创性的治疗策略。免疫疗法采用不同的免疫学方法，如抗体、疫苗、免疫佐剂和细胞因子，来刺激宿主免疫系统对抗疾病。在癌症治疗中，光疗不仅能破坏肿瘤细胞，还能诱导免疫原性肿瘤细胞死亡，从而引发全身性抗肿瘤免疫反应。当与免疫疗法结合时，光疗的效果可以增强。由于纳米材料具有特殊的物理、化学，有时还有免疫学特性，因此也被用于增强光疗。本文综述了基于纳米技术的光疗的最新进展，包括纳米光热疗法、纳米光化学疗法和纳米光免疫疗法在癌症治疗中的应用。具体而言，我们重点介绍了纳米光疗所诱导的免疫反应。
