Continuous Flow Alcoholysis of Dialkyl H-Phosphonates with Aliphatic Alcohols.

The continuous flow alcoholysis of dialkyl -phosphonates by aliphatic alcohols in the absence of a catalyst was elaborated using a microwave (MW) reactor equipped with a flow cell. By the precise control of the reaction conditions, the synthesis could be fine-tuned towards dialkyl -phosphonates with two different and with two identical alkyl groups. In contrast to the "traditional" batch alcoholysis, flow approaches required shorter reaction times, and the products became available at a larger scale.