Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary.
Molecules. 2018 Jul 3;23(7):1618. doi: 10.3390/molecules23071618.
The continuous flow alcoholysis of dialkyl -phosphonates by aliphatic alcohols in the absence of a catalyst was elaborated using a microwave (MW) reactor equipped with a flow cell. By the precise control of the reaction conditions, the synthesis could be fine-tuned towards dialkyl -phosphonates with two different and with two identical alkyl groups. In contrast to the "traditional" batch alcoholysis, flow approaches required shorter reaction times, and the products became available at a larger scale.
使用配备流动池的微波（MW）反应器详细阐述了脂肪醇在不存在催化剂的情况下对二烷基膦酸盐的连续流动醇解反应。通过精确控制反应条件，可以将合成物精细调整为具有两种不同烷基和两种相同烷基的二烷基膦酸盐。与“传统”的分批醇解相比，流动方法需要更短的反应时间，并且可以在更大的规模上获得产物。
