Novoa Ana M, de Olalla Patricia G, Clos Roser, Orcau Angels, Rodríguez-Sanz Maica, Caylà Joan A
Epidemiology Department, Public Health Agency of Barcelona, Spain.
Curr HIV Res. 2008 Jan;6(1):77-81. doi: 10.2174/157016208783572017.
To analyze the factors associated with survival and to describe the specific causes of death in a large cohort of individuals with Acquired Immune Deficiency Syndrome (AIDS) in the Highly Active Antiretroviral Therapy (HAART) era.
Subjects over 13 years old recorded in the AIDS registry of Barcelona and diagnosed between 1997-2005 were included. Survival analysis was performed. Causes of death were classified as being HIV-related or non-HIV-related.
A total of 1,759 cases were analyzed, 640 (36.3%) of them died during the follow-up. The cumulative probability of survival at five years was of 64% (95% C.I. 62%-67%). The cause of death was non-HIV-related in 28.9% of the cases, among which the most frequent were cancers (20.8%) and liver diseases (18.8%).
An increase in the proportion of non-HIV-related deaths has been observed compared to that in the pre-HAART era. The case management of HIV-infected people must be re-directed to influence the risk factors associated with these increasing causes of death.
分析与生存相关的因素，并描述高效抗逆转录病毒治疗（HAART）时代一大群获得性免疫缺陷综合征（AIDS）患者的具体死亡原因。
纳入巴塞罗那艾滋病登记处记录的、1997年至2005年间诊断的13岁以上受试者。进行生存分析。死亡原因分为与HIV相关或与HIV无关。
共分析了1759例病例，其中640例（36.3%）在随访期间死亡。五年时的累积生存概率为64%（95%置信区间62%-67%）。28.9%的病例死亡原因与HIV无关，其中最常见的是癌症（20.8%）和肝脏疾病（18.8%）。
与HAART时代之前相比，已观察到与HIV无关的死亡比例有所增加。必须重新调整HIV感染者的病例管理，以影响与这些不断增加的死亡原因相关的危险因素。
