Krauskopf Katherine, Van Natta Mark L, Danis Ronald P, Gangaputra Sapna, Ackatz Lori, Addessi Adrienne, Federman Alex D, Branch Andrea D, Meinert Curtis L, Jabs Douglas A
J Int Assoc Provid AIDS Care. 2013 Sep-Oct;12(5):325-33. doi: 10.1177/2325957413491432.
It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors.
Prospective observational cohort included 2390 patients with AIDS (1998-2011). Univariate analysis was used to assess the impact of traditional- and AIDS-related risk factors for HTN prevalence and incidence. Multivariate regression analyses were used to evaluate the adjusted impact of these factors.
Hypertension prevalence was 22%(95% confidence interval [CI] 21%-24%) and was associated with traditional HTN risk factors (age, black race, and higher weight) as well as diabetes, hyperlipidemia, time since AIDS diagnosis, and higher CD4 counts. Hypertension incidence was 64.1 per 1000 person-years (95% CI 58.7/1000-69.9/1000). Age, race, weight, and diabetes were associated with incident HTN but HIV-specific factors were not.
Hypertension, a prevalent cardiovascular risk factor in patients with AIDS, is associated with traditional and metabolic risk factors.
尚不清楚与HIV相关的因素是否会改变高血压（HTN）的风险。在一组艾滋病患者中，作者确定了HTN的发病率和患病率，并评估了相关的传统因素、HIV特异性因素和视网膜血管因素。
前瞻性观察队列包括2390例艾滋病患者（1998 - 2011年）。采用单因素分析评估传统和艾滋病相关危险因素对HTN患病率和发病率的影响。多因素回归分析用于评估这些因素的校正影响。
高血压患病率为22%（95%置信区间[CI] 21% - 24%），与传统的HTN危险因素（年龄、黑人种族和体重增加）以及糖尿病、高脂血症、自艾滋病诊断以来的时间和较高的CD4计数有关。高血压发病率为每1000人年64.1例（95% CI 58.7/1000 - 69.9/1000）。年龄、种族、体重和糖尿病与HTN发病有关，但HIV特异性因素无关。
高血压是艾滋病患者中常见的心血管危险因素，与传统和代谢危险因素有关。
