Kristensen A T, Wiinberg B, Jessen L R, Andreasen E, Jensen A L
Department of Small Animal Clinical Sciences, The Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark.
J Vet Intern Med. 2008 Jan-Feb;22(1):140-7. doi: 10.1111/j.1939-1676.2008.0030.x.
Abnormal routine coagulation assay results have been reported to be common in veterinary patients with neoplasia, but the overall hemostatic functional state, including hypercoagulability, has not been described.
The overall hemostatic functional state, including hypercoagulability, can be assessed in dogs with neoplasia by tissue factor (TF)-activated thromboelastography (TEG).
Thirty-six dogs with malignant neoplasia and 13 dogs with benign neoplasia presented to the Small Animal Veterinary Teaching Hospital, The University of Copenhagen, Frederiksberg, Denmark.
Prospective study evaluating the overall hemostatic functional state in dogs with neoplasia by a newly validated TF-activated TEG assay and routine coagulation parameters activated partial thromboplastin time (aPTT), prothrombin time (PT), platelet count, and D-dimer concentration.
Hemostatic dysfunction was observed in 28/49 (57%) dogs with neoplasia. Twenty-four were dogs with malignant neoplasia, the majority of which 18/36 (50%) were hypercoagulable, whereas 6/36 (17%) were hypocoagulable. All hypocoagulable dogs had metastatic disease. The proportion of dogs with altered hemostasis was significantly different between dogs with malignant and benign neoplasia.
TF-activated TEG detected hypercoagulable and hypocoagulable states in this population of dogs with neoplasia. The most common hemostatic abnormality in dogs with malignant neoplasia was hypercoagulability. These findings suggest that this novel hemostatic function test may be of value as a cage side method for the assessment of overall hemostatic function in dogs with cancer, including the detection of both hyper- and hypocoagulable states as well as mixed disorders.
据报道，肿瘤性疾病的兽医患者常出现常规凝血检测结果异常，但包括高凝状态在内的整体止血功能状态尚未见描述。
通过组织因子（TF）激活的血栓弹力图（TEG）可评估肿瘤性疾病犬的包括高凝状态在内的整体止血功能状态。
36只患有恶性肿瘤的犬和13只患有良性肿瘤的犬被送至丹麦哥本哈根大学弗雷德里克斯堡小动物兽医教学医院。
一项前瞻性研究，通过新验证的TF激活TEG检测法和常规凝血参数活化部分凝血活酶时间（aPTT）、凝血酶原时间（PT）、血小板计数及D-二聚体浓度，评估肿瘤性疾病犬的整体止血功能状态。
49只肿瘤性疾病犬中有28只（57%）出现止血功能障碍。24只为患有恶性肿瘤的犬，其中大多数18/36（50%）为高凝状态，而6/36（17%）为低凝状态。所有低凝状态的犬均有转移性疾病。恶性肿瘤犬和良性肿瘤犬中止血功能改变的犬比例有显著差异。
TF激活的TEG在这群肿瘤性疾病犬中检测到了高凝和低凝状态。患有恶性肿瘤的犬最常见的止血异常是高凝状态。这些发现表明，这种新型止血功能检测法作为一种床边方法，可能对评估癌症犬的整体止血功能有价值，包括检测高凝和低凝状态以及混合性疾病。
