Ke Chiao-Hsu, Liu Cheng-Chi, Wang Shang-Lin, Lin Chen-Si
Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan.
Graduate Institute of Veterinary Clinical Science, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan.
Animals (Basel). 2023 Mar 7;13(6):969. doi: 10.3390/ani13060969.
Previous studies have reported that dogs with neoplasms had elevated D-dimer levels. However, few studies have addressed whether D-dimer could be an indicator of tumor burden. The clinical significance of paired analysis of pre- and post-operation of D-dimer levels in dogs has rarely been described. The present study investigated the values of D-dimer levels and their correlated hemostatic alterations in dogs with surgically removable benign and malignant tumors. This study analyzed 30 clinically healthy and 30 tumor-bearing dogs and evaluated the hemostatic functions including D-dimer, thromboelastography G (TEG G), fibrinogen, activated partial thromboplastin time (aPTT), prothrombin time, and platelet count. The median level of pre-treatment D-dimer was 0.8 µg/mL (range: 0.1-6.3 µg/mL), whereas the control dogs exhibited a median value of 0.1 µg/mL (range: 0.1-0.1 µg/mL, < 0.0001). After tumorectomy, the median levels of D-dimer ( < 0.0001), fibrinogen ( < 0.0001), TEG G value ( < 0.01), and aPTT ( < 0.05) were significantly lower than those of the pre-treatment samples. However, further studies are needed to clarify the values of other hemostatic evaluations. The study revealed the clinical significance of D-dimer and its correlated hemostatic parameters by paired analysis in dogs with tumors. Though more cases are needed for solid confirmation, these values could be potential tumor biomarkers for dogs.
先前的研究报道，患有肿瘤的犬类D - 二聚体水平升高。然而，很少有研究探讨D - 二聚体是否可作为肿瘤负荷的指标。犬类手术前后D - 二聚体水平配对分析的临床意义鲜有描述。本研究调查了患有可手术切除的良性和恶性肿瘤的犬类D - 二聚体水平及其相关止血改变的值。本研究分析了30只临床健康犬和30只患肿瘤犬，并评估了包括D - 二聚体、血栓弹力图G（TEG G）、纤维蛋白原、活化部分凝血活酶时间（aPTT）、凝血酶原时间和血小板计数在内的止血功能。治疗前D - 二聚体的中位数水平为0.8 µg/mL（范围：0.1 - 6.3 µg/mL），而对照犬的中位数为0.1 µg/mL（范围：0.1 - 0.1 µg/mL，P < 0.0001）。肿瘤切除术后，D - 二聚体（P < 0.0001）、纤维蛋白原（P < 0.0001）、TEG G值（P < 0.01）和aPTT（P < 0.05）的中位数水平显著低于治疗前样本。然而，需要进一步研究以阐明其他止血评估的值。该研究通过对患肿瘤犬进行配对分析揭示了D - 二聚体及其相关止血参数的临床意义。尽管需要更多病例进行确凿证实，但这些值可能是犬类潜在的肿瘤生物标志物。
