Prell G D, Green J P
Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, New York 10029.
Agents Actions Suppl. 1991;33:343-63. doi: 10.1007/978-3-0348-7309-3_25.
In cerebrospinal fluid, levels of the histamine metabolites, tele-methylhistamine and tele-methylimidazole-acetic acid, were higher in elderly than in young people, and women had higher levels than men. Therefore, age and gender should be considered in studies of histamine metabolites as exemplified by their measurements in cerebrospinal fluid of patients with Huntington's disease. Levels of pros-methylimidazoleacetic acid, an isomer of tele-methylimidazoleacetic acid and not a metabolite of histamine, were higher in cerebrospinal fluid of men than of women. Levels of pros-methylimidazoleacetic acid in cerebrospinal fluid were highly positively correlated with the severity of Parkinson's disease in a group of non-medicated, mildly to moderately affected patients.
在脑脊液中，组胺代谢产物N-甲基组胺和N-甲基咪唑乙酸的水平在老年人中高于年轻人，且女性高于男性。因此，在组胺代谢产物的研究中应考虑年龄和性别因素，如在亨廷顿舞蹈症患者脑脊液中的测量结果所示。N-甲基咪唑乙酸的异构体、非组胺代谢产物前甲基咪唑乙酸在男性脑脊液中的水平高于女性。在一组未用药、轻度至中度受影响的帕金森病患者中，脑脊液中前甲基咪唑乙酸的水平与帕金森病的严重程度高度正相关。
