Khandelwal J K, Hough L B, Green J P
Klin Wochenschr. 1982 Sep 1;60(17):914-8. doi: 10.1007/BF01716947.
The concentrations of histamine, t-methylhistamine and t-methylimidazoleacetic acid were measured in human cerebrospinal fluid, plasma and urine, Especially noteworthy are the levels of histamine in cerebrospinal fluid which are far higher than those of t-methylhistamine and of t-methylimidazoleacetic acid, and high enough to stimulate histamine receptors in the central nervous system. It is suggested that mast cells, which surround the subarachnoid space, may contribute histamine to the cerebrospinal fluid and may offer a target for drugs and for immunologic actions. The t-methylhistamine and t-methylimidazoleacetic acid levels in cerebrospinal fluid may reflect central histaminergic activity, although a source of these metabolites in addition to histamine needs to be considered.
对人脑脊液、血浆和尿液中的组胺、t-甲基组胺和t-甲基咪唑乙酸浓度进行了测量。特别值得注意的是，脑脊液中的组胺水平远高于t-甲基组胺和t-甲基咪唑乙酸的水平，并且高到足以刺激中枢神经系统中的组胺受体。有人提出，围绕蛛网膜下腔的肥大细胞可能向脑脊液中释放组胺，并可能成为药物和免疫作用的靶点。脑脊液中的t-甲基组胺和t-甲基咪唑乙酸水平可能反映中枢组胺能活性，不过除了组胺之外，还需要考虑这些代谢产物的来源。
