在MTAD中用氯己定替代强力霉素：对粪肠球菌菌株的抗菌效果

The substitution of chlorhexidine for doxycycline in MTAD: the antibacterial efficacy against a strain of Enterococcus faecalis.

作者信息

Shabahang Shahrokh, Aslanyan Joseph, Torabinejad Mahmoud

机构信息

Department of Endodontics, School of Dentistry, Loma Linda University, Loma Linda, California 92354, USA.

出版信息

J Endod. 2008 Mar;34(3):288-90. doi: 10.1016/j.joen.2007.12.012.

DOI:10.1016/j.joen.2007.12.012

PMID:18291277

Abstract

The antimicrobial effect of MTAD has been largely attributed to the presence of doxycycline. In the present study, chlorhexidine was added to or substituted for doxycycline to compare these three formulations in their ability to disinfect extracted human teeth infected with Enterococcus faecalis. Ten teeth were used in each group along with positive and negative controls. The teeth were treated according to previously published protocols. None of the samples treated with MTAD or MTAD + chlorhexidine showed the presence of residual bacteria. In contrast, 7 of 10 samples treated with MCAD (chlorhexidine substituted for doxycycline) showed positive cultures of E. faecalis. The results clearly showed that although the addition of chlorhexidine did not negatively impact the efficacy of MTAD, the substitution of this antimicrobial agent for doxycycline significantly reduces the efficacy of the solution.

摘要

MTAD的抗菌作用很大程度上归因于强力霉素的存在。在本研究中，将洗必泰添加到强力霉素中或用其替代强力霉素，以比较这三种配方对感染粪肠球菌的拔除人类牙齿进行消毒的能力。每组使用10颗牙齿，并设置阳性和阴性对照。牙齿按照先前发表的方案进行处理。用MTAD或MTAD+洗必泰处理的样本均未显示有残留细菌。相比之下，用MCAD（用洗必泰替代强力霉素）处理的10个样本中有7个显示粪肠球菌培养呈阳性。结果清楚地表明，虽然添加洗必泰不会对MTAD的疗效产生负面影响，但用这种抗菌剂替代强力霉素会显著降低溶液的疗效。