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飞秒激光辅助角膜基质内植入角膜环段(KeraRing)治疗圆锥角膜患者的一年期结果。

One-year results of intrastromal corneal ring segment implantation (KeraRing) using femtosecond laser in patients with keratoconus.

作者信息

Coskunseven Efekan, Kymionis George D, Tsiklis Nikolaos S, Atun Serife, Arslan Ebru, Jankov Mirko R, Pallikaris Ioannis G

机构信息

Dunya Eye Hospital, Istanbul, Turkey.

出版信息

Am J Ophthalmol. 2008 May;145(5):775-9. doi: 10.1016/j.ajo.2007.12.022. Epub 2008 Mar 4.

Abstract

PURPOSE

To report the results of intrastromal corneal ring segment [ICRS] (KeraRing; Mediphacos, Belo Horizonte, Brazil) implantation using a femtosecond laser (IntraLase Corp, Irvine, California, USA) in keratoconic patients.

DESIGN

Retrospective, noncomparative, interventional study.

METHODS

Thirty-two keratoconic patients (50 eyes) who underwent ICRS insertion using a femtosecond laser for channel creation and completed at least one year of follow-up were included in this study. Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), refraction, topographic findings, and adverse events were assessed.

RESULTS

No intraoperative complications were demonstrated in this series of patients. At the first postoperative day, segment migration to the incision site was seen in three eyes (6%; early postoperative complication). To avoid melting, we repositioned the migrated segment away from the incision site. Serious second migration was not seen and we did not need to reposition any segment again. At the last postoperative examination, there was a statistically significant reduction in the spherical equivalent refractive error compared with that observed at the examination before implantation (mean +/- standard deviation, -5.62 +/- 4.15 diopters [D; range, -23.62 to 0.50 D] to -2.49 +/- 2.68 D [range, -11.12 to 3.5 D]; P < .001). The UCVA before implantation was 20/40 or worse in 47 eyes (94%; range, counting fingers to 20/30), whereas at the last follow-up examination, 14 (28%) of 50 eyes had a UCVA of 20/40 or better (range, counting fingers to 20/25). Nine eyes (18%) maintained the preimplantation BSCVA, whereas 39 eyes (68%) experienced a BSCVA gain of one to four lines at the last follow-up examination. Only in two eyes (4%; two patients) with advanced keratoconus (stage III) was there a decrease of up to two lines. Despite this deterioration in BSCVA, the patients did not want to remove the ICRSs, because there was an increase of UCVA. No late postoperative complications were observed during the follow-up period.

CONCLUSIONS

ICRS (KeraRing) implantation using femtosecond laser for tunnel creation is a minimally invasive procedure for improving visual acuity (both UCVA and BSCVA) in keratoconic patients.

摘要

目的

报告在圆锥角膜患者中使用飞秒激光(美国加利福尼亚州欧文市IntraLase公司)植入基质内角膜环片(ICRS,KeraRing;巴西贝洛奥里藏特市Mediphacos公司)的结果。

设计

回顾性、非对比性、干预性研究。

方法

本研究纳入了32例圆锥角膜患者(50只眼),这些患者使用飞秒激光制作隧道后植入了ICRS,并完成了至少一年的随访。评估了未矫正视力(UCVA)、最佳眼镜矫正视力(BSCVA)、验光、地形图检查结果及不良事件。

结果

该系列患者术中未出现并发症。术后第1天,3只眼(6%)出现环片向切口部位移位(早期术后并发症)。为避免环片融化,我们将移位的环片从切口部位移开重新定位。未出现严重的二次移位,也无需再次对任何环片进行重新定位。在术后最后一次检查时,与植入前检查相比,等效球镜屈光不正有统计学意义的降低(平均值±标准差,从-5.62±4.15屈光度[D;范围,-23.62至0.50 D]降至-2.49±2.68 D[范围,-11.12至3.5 D];P<0.001)。植入前50只眼中47只眼(94%;范围,指数视力至20/30)的UCVA为20/40或更差,而在最后一次随访检查时,50只眼中14只眼(28%)的UCVA为20/40或更好(范围,指数视力至20/25)。9只眼(18%)维持了植入前的BSCVA,而39只眼(68%)在最后一次随访检查时BSCVA提高了1至4行。仅2只眼(4%;2例患者)患有晚期圆锥角膜(III期),BSCVA下降了多达2行。尽管BSCVA有所下降,但患者因UCVA提高而不愿取出ICRS。随访期间未观察到晚期术后并发症。

结论

使用飞秒激光制作隧道植入ICRS(KeraRing)是一种改善圆锥角膜患者视力(UCVA和BSCVA)的微创手术。

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