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圆锥角膜患者选择标准及角膜内环植入术适应症

Criteria for patient selection and indication for intracorneal ring segments in keratoconus.

作者信息

Vega Alfredo, Alió Jorge L

机构信息

Grupo Miranza, Alicante, Spain.

Universidad Miguel Hernandez de Elche, Alicante, Spain.

出版信息

Eye Vis (Lond). 2024 Mar 26;11(1):13. doi: 10.1186/s40662-024-00379-0.

Abstract

BACKGROUND

Keratoconus is an ectatic, progressive corneal disorder characterized by alterations in the morphology of the corneal tissue that leads to limitation of visual function of the patient. Intracorneal ring segments (ICRS) are small synthetic devices that are implanted in the corneal stromal in order to regularize the morphology of the tissue therefore improving the visual function and the quality of life of the patients.

MAIN TEXT

The present narrative review summarizes the main scientific articles developed by the authors in relation to the clinical outcomes and long-term results of ICRS in the treatment of keratoconus. It was found that those patients that benefit the most from this surgical intervention are those that have the most severe form of keratoconus. Additionally, patients with good visual function, those with more than 0.9 in the decimal scale are at risk of losing visual acuity after ICRS implantation. In relation to long-term results, scientific investigations published by the authors demonstrate that ICRS is a stable procedure after long period of time in terms of vision, refraction, and topographic variables in those patients with stable keratoconus. However, in patients with keratoconus and signs of progression, ICRS may not have the capability of halting the progression of the disease. Using artificial intelligence to guide ICRS implantation provide better clinical outcomes and improvement in corneal higher-order aberrations in patients with keratoconus in comparison to those treated using the commercial nomogram of implantation.

CONCLUSIONS

ICRS is a safe surgical procedure in the treatment of keratoconus. Patients that benefit most from the surgery are those with a significant visual impairment. ICRS should not be considered in patients with good visual function because of the risk of losing lines of vision. Long-term follow-up demonstrate stability of the clinical outcomes in patients with stable keratoconus although ICRS may not have the ability of halting the progression of the disease. New technologies based artificial intelligence improved the indications and the clinical outcomes of keratoconus patients treated with ICRS.

摘要

背景

圆锥角膜是一种扩张性、进行性角膜疾病,其特征是角膜组织形态改变,导致患者视功能受限。角膜内环片(ICRS)是一种小型合成装置,植入角膜基质中以规整组织形态,从而改善患者的视功能和生活质量。

正文

本叙述性综述总结了作者发表的关于ICRS治疗圆锥角膜的临床结果和长期疗效的主要科学文章。研究发现,从这种手术干预中获益最大的患者是那些圆锥角膜病情最严重的患者。此外,视功能良好(小数视力表视力大于0.9)的患者在植入ICRS后有视力下降的风险。关于长期疗效,作者发表的科学研究表明,对于圆锥角膜病情稳定的患者,从视力、屈光和地形图变量方面来看,ICRS在长时间后是一种稳定的手术方式。然而,对于患有圆锥角膜且有病情进展迹象的患者,ICRS可能无法阻止疾病的进展。与使用商业植入方案治疗的患者相比,使用人工智能指导ICRS植入可使圆锥角膜患者获得更好的临床结果,并改善角膜高阶像差。

结论

ICRS是治疗圆锥角膜的一种安全手术方式。从手术中获益最大的患者是那些有明显视力损害的患者。由于存在视力下降风险,视功能良好的患者不应考虑使用ICRS。长期随访表明,圆锥角膜病情稳定的患者临床结果具有稳定性,尽管ICRS可能无法阻止疾病进展。基于人工智能的新技术改善了接受ICRS治疗的圆锥角膜患者的适应证和临床结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49de/10964652/72deb4c735b3/40662_2024_379_Fig1_HTML.jpg

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