Guarnelli Maria Elena, Franceschetti Giovanni, Manfrini Roberta, Trombelli Leonardo
Research Center for Study of Periodontal Diseases, University of Ferrara, Ferrara, Italy.
J Clin Periodontol. 2008 Apr;35(4):333-41. doi: 10.1111/j.1600-051X.2008.01199.x. Epub 2008 Feb 20.
The aim of the present pilot randomized clinical trial was to evaluate the effects of ultrasonic mechanical instrumentation (UMI) associated with the professional use of chlorhexidine (CHX) formulations compared with UMI alone during periodontal supportive therapy in patients with generalized aggressive periodontis (G-AgP).
Nine patients (test group) received a single session of UMI associated with subgingival irrigation under cavitation with CHX 0.02%. A 0.2% CHX solution was used for professional tongue brushing and mouthrinsing. Ten patients (control group) received a similar session of UMI associated with subgingival irrigation and professional tongue brushing and mouthrinsing with a control formulation. Clinical and microbiological parameters were assessed pre-treatment at 3, 6 and 12 weeks post-treatment.
UMI either with or without additional CHX use determined a significant reduction of supragingival plaque and gingival inflammation as well as a significant reduction of subgingival bacterial pathogens. The additional use of CHX did not result in any additional clinical and microbiological benefit with respect to mere UMI.
The adjunctive professional use of CHX formulations to UMI seems to produce no additional effects over UMI alone during supportive therapy in G-AgP patients.
本初步随机临床试验的目的是评估在广泛侵袭性牙周炎（G-AgP）患者的牙周支持治疗期间，与单独使用超声机械器械（UMI）相比，超声机械器械联合洗必泰（CHX）制剂专业应用的效果。
9名患者（试验组）接受了一次UMI治疗，并在空化作用下进行0.02%CHX的龈下冲洗。使用0.2%CHX溶液进行专业的舌面刷牙和漱口。10名患者（对照组）接受了类似的UMI治疗，并进行龈下冲洗以及使用对照制剂进行专业的舌面刷牙和漱口。在治疗前、治疗后3周、6周和12周评估临床和微生物学参数。
无论是否额外使用CHX，UMI均能显著减少龈上菌斑和牙龈炎症，以及显著减少龈下细菌病原体。与单纯UMI相比，额外使用CHX并未带来任何额外的临床和微生物学益处。
在G-AgP患者的支持治疗期间，CHX制剂与UMI联合专业应用相对于单独使用UMI似乎没有额外效果。
