Piao Xiang-Lan, Jang Moon Hee, Cui Jian, Piao Xiangshu
Chinese Minority Traditional Medical Center, College of Life and Environmental Sciences, Central University for Nationalities, Beijing 100081, China.
Bioorg Med Chem Lett. 2008 Mar 15;18(6):1980-4. doi: 10.1016/j.bmcl.2008.01.115. Epub 2008 Feb 2.
Bioactivity-guided fractionation of the methanol extract of the fruits of Forsythia suspensa Vahl has led to the isolation of two new monoepoxylignans, forsythialan A (1) and B (2), together with a known tetrahydrofurofuran lignan, phillyrin (3). The structures of compounds 1 and 2 were elucidated by spectroscopic methods. The antioxidant activities of these lignans have been assessed by evaluating their protective effects against peroxynitrite-induced oxidative stress. The compounds 1 and 2 showed protective effects against renal epithelial cell injury by 3-morpholinosydnonimine (SIN-1), a peroxynitrite generator. The relatively stronger antioxidant activities of compounds 1 and 2 may be associated with the presence of aromatic hydroxy function.
对连翘果实甲醇提取物进行生物活性导向分离，得到了两种新的单环氧木脂素，连翘脂素A（1）和B（2），以及一种已知的四氢呋喃呋喃木脂素，连翘苷（3）。通过光谱方法阐明了化合物1和2的结构。通过评估这些木脂素对过氧亚硝酸盐诱导的氧化应激的保护作用，对其抗氧化活性进行了评价。化合物1和2对过氧亚硝酸盐发生器3-吗啉代辛二亚胺（SIN-1）诱导的肾上皮细胞损伤具有保护作用。化合物1和2相对较强的抗氧化活性可能与芳香羟基官能团的存在有关。
