Kurucz Eva, Váczi B, Márkus R, Laurinyecz Barbara, Vilmos P, Zsámboki J, Csorba Kinga, Gateff Elisabeth, Hultmark D, Andó I
Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary.
Acta Biol Hung. 2007;58 Suppl:95-111. doi: 10.1556/ABiol.58.2007.Suppl.8.
We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria. On the basis of the expression or the lack of expression of blood cell antigens the following hemocyte populations have been defined: crystal cells, plasmatocytes, lamellocytes and precursor cells. The expression of the antigens and thus the different cell types are developmentally regulated. The hemocytes are arranged in four main compartments: the circulating blood cells, the sessile tissue, the lymph glands and the posterior hematopoietic tissue. Each hemocyte compartment has a specific and characteristic composition of the various cell types. The described markers represent the first successful attempt to define hemocyte lineages by immunological markers in Drosophila and help to define morphologically, functionally, spatially and developmentally distinct subsets of hemocytes.
我们基于细胞类型特异性抗原的表达分析了果蝇血细胞的异质性。这些抗原表征了不同的亚群，它们与根据形态学标准定义的亚群部分重叠。根据血细胞抗原的表达或不表达，已定义了以下血细胞群体：晶细胞、浆细胞、片层细胞和前体细胞。抗原的表达以及不同的细胞类型受到发育调控。血细胞分布在四个主要区域：循环血细胞、固着组织、淋巴腺和后造血组织。每个血细胞区域具有各种细胞类型的特定且独特的组成。所描述的标记代表了在果蝇中通过免疫标记定义血细胞谱系的首次成功尝试，并有助于在形态学、功能、空间和发育上定义不同的血细胞亚群。
